Mammalian RNA polymerase II core promoters: insights from genome-wide studies

Sandelin, A, Carninci, P, Lenhard, B, Ponjavic, J, Hayashizaki, Y and Hume, DA (2007) Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nature Reviews Genetics, 8 6: 424-436. doi:10.1038/nrg2026


Author Sandelin, A
Carninci, P
Lenhard, B
Ponjavic, J
Hayashizaki, Y
Hume, DA
Title Mammalian RNA polymerase II core promoters: insights from genome-wide studies
Journal name Nature Reviews Genetics   Check publisher's open access policy
ISSN 1471-0056
Publication date 2007
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrg2026
Volume 8
Issue 6
Start page 424
End page 436
Total pages 13
Place of publication London
Publisher Nature Publishing Group
Collection year 2008
Language eng
Subject C1
270202 Genome Structure
780106 Political science and public policy
Abstract The identification and characterization of mammalian core promoters and transcription start sites is a prerequisite to understanding how RNA polymerase II transcription is controlled. New experimental technologies have enabled genome-wide discovery and characterization of core promoters, revealing that most mammalian genes do not conform to the simple model in which a TATA box directs transcription from a single defined nucleotide position. In fact, most genes have multiple promoters, within which there are multiple start sites, and alternative promoter usage generates diversity and complexity in the mammalian transcriptome and proteome. Promoters can be described by their start site usage distribution, which is coupled to the occurrence of cis-regulatory elements, gene function and evolutionary constraints. A comprehensive survey of mammalian promoters is a major step towards describing and understanding transcriptional control networks.
Keyword Genetics & Heredity
Transcription-factor-binding
High-throughput Analysis
Gene-expression
Start Sites
Dependent Transcription
Accurate Transcription
Alternative Promoters
Nucleosome Density
Noncoding Rnas
Cap Analysis
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Journal Article Import (ISI/CVs)
2008 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Created: Mon, 18 Feb 2008, 17:14:09 EST