Neogenin: One receptor, many functions

Wilson, Nicole H. and Key, Brian (2007) Neogenin: One receptor, many functions. International Journal of Biochemistry & Cell Biology, 39 5: 874-878. doi:10.1016/j.biocel.2006.10.023


Author Wilson, Nicole H.
Key, Brian
Title Neogenin: One receptor, many functions
Journal name International Journal of Biochemistry & Cell Biology   Check publisher's open access policy
ISSN 1357-2725
Publication date 2007
Sub-type Article (original research)
DOI 10.1016/j.biocel.2006.10.023
Volume 39
Issue 5
Start page 874
End page 878
Total pages 5
Editor G. J. Laurent
Place of publication Oxford
Publisher Pergamon-elsevier Science Ltd
Collection year 2008
Language eng
Subject 730104 Nervous system and disorders
320704 Cellular Nervous System
C1
Abstract Neogenin is a multifunctional transmembrane receptor belonging to the immunoglobulin superfamily. It displays identical secondary structure to deleted in colorectal cancer (DCC), a netrin receptor that is involved in axon guidance and cell survival. Like DCC, neogenin is able to transduce signals elicited by netrin. These neogenin-netrin interactions have been implicated in tissue morphogenesis, angiogenesis, myoblast differentiation and most recently in axon guidance. Neogenin is also a receptor for repulsive guidance molecule, a glycosylphosphatidylinositol-linked protein involved in neuronal differentiation, apoptosis and repulsive axon guidance. Numerous studies have been started to elucidate the in vivo functions of neogenin, and its role in multiple aspects of development and homeostasis. (C) 2006 Elsevier Ltd. All rights reserved.
Keyword Biochemistry & Molecular Biology
Cell Biology
neogenin
RGM
netrin
axon
chemorepulsion
chemoattraction
Repulsive Guidance Molecule
Netrin Receptor
Neuronal Differentiation
Colorectal-cancer
Rgm
Expression
Dcc
Patterns
Survival
Growth
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Mon, 18 Feb 2008, 17:12:20 EST