Cough throughout life: Children, adults and the senile

Chang, Anne B. and Widdicombe, John G. (2007) Cough throughout life: Children, adults and the senile. Pulmonary Pharmacology and Therapeutics, 20 4: 371-382. doi:10.1016/j.pupt.2006.10.004

Author Chang, Anne B.
Widdicombe, John G.
Title Cough throughout life: Children, adults and the senile
Journal name Pulmonary Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 1094-5539
Publication date 2007
Sub-type Article (original research)
DOI 10.1016/j.pupt.2006.10.004
Volume 20
Issue 4
Start page 371
End page 382
Total pages 12
Place of publication London, United Kingdom
Publisher Academic Press
Collection year 2008
Language eng
Abstract We review cough from premature birth, mature neonatal life, in childhood and adult life, and in old age. There is a regrettable lack of definitive studies, but many clues in the literature. The cough reflex seems weak in premature infants, but develops with maturity. It is pronounced in childhood, but there seem to be no studies comparing its strength then with that in adulthood. In old age the cough may weaken, as indicated by the prevalence of aspiration pneumonia. These changes are presumably related to the development and degeneration of the afferent and central nervous pathways for cough, which may be reflected in the changes in laryngeal muscle function with age. There is much evidence that age influences the development of the respiratory system in general, and of the immune system which would affect the degree, frequency and clinical issues of cough. Other factors that limit our understanding of the changes in cough with age include the reporting of cough by parents in infants and carers in old age and the use of different diagnostic criteria throughout life. Age-related variation in cough sensitivity seems to be well established, but its quantitation and mechanisms require much further research. Crown Copyright (c) 2006 Published by Elsevier Ltd. All rights reserved.
Keyword Adults
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 26 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 32 times in Scopus Article | Citations
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Created: Mon, 18 Feb 2008, 17:08:46 EST