Mouse molar dentin size/shape is dependent on growth hormone status

Smid, J. R., Rowland, J. E., Young, W. G., Coschigano, K. T., Kopchick, J. J. and Waters, M. J. (2007) Mouse molar dentin size/shape is dependent on growth hormone status. Journal of Dental Research, 86 5: 463-468. doi:10.1177/154405910708600514

Author Smid, J. R.
Rowland, J. E.
Young, W. G.
Coschigano, K. T.
Kopchick, J. J.
Waters, M. J.
Title Mouse molar dentin size/shape is dependent on growth hormone status
Journal name Journal of Dental Research   Check publisher's open access policy
ISSN 0022-0345
Publication date 2007-05
Sub-type Article (original research)
DOI 10.1177/154405910708600514
Volume 86
Issue 5
Start page 463
End page 468
Total pages 6
Editor A. Smith
Place of publication Alexandria, United States
Publisher International Association for Dental Research
Collection year 2008
Language eng
Subject C1
730112 Oro-dental and disorders
320899 Dentistry not elsewhere classified
Abstract Growth hormone ( GH) status affects dental development, but how GH influences tooth size/shape is unclear. Since GH affects dental epithelial proliferation, we hypothesized that GH influences the tooth crown and root dimensions. Dentin matrix dimensions were measured in longitudinal sections of decalcified first mandibular molars from 3 genetically modified mice: giant ( GH-Excess) mice and dwarf ( GH-Antagonist and GH-Receptor-Knockout) mice. GH status was found to influence crown width, root length, and dentin thickness. Analysis of these data suggests that GH influences both tooth crown and root development prior to dentinogenesis as well as during appositional growth of dentin. This is concordant with the expression of paracrine GH and GH receptors during tooth bud morphogenesis, and of GH receptors in the enamel organ, dental papilla, and Hertwig's epithelial root sheath during dentinogenesis. Based on prior studies, these GH morphogenetic actions may be mediated by the induction of both bone morphogenetic protein and insulin-like growth factor-1 expression.
Keyword Dentistry, Oral Surgery & Medicine
dentin dimensions
tooth morphogenesis
growth hormone
GH transgenic mice
GH receptor-knockout mice
Lewis Dwarf Rat
Transgenic Mice
Tooth Development
Q-Index Code C1
Q-Index Status Confirmed Code

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Created: Mon, 18 Feb 2008, 16:57:51 EST