Central nervous system infection is an important cause of death in underfives hospitalised with World Health Organization (WHO) defined severe and very severe pneumonia

Lupisan, Socorro P., Ruutu, Petri, Abucejo-Ladesma, P. Erma, Quiambao, Beatriz P., Gozum, Lorena, Sombrero, Lydia T., Romano, Vicente, Riley, Ian, Simoes, Eric A. F. and Acute Respiratory Infections Vaccines (ARIVAC) Consortium (2007) Central nervous system infection is an important cause of death in underfives hospitalised with World Health Organization (WHO) defined severe and very severe pneumonia. Vaccine, 25 13: 2437-2444. doi:10.1016/j.vaccine.2006.09.017


Author Lupisan, Socorro P.
Ruutu, Petri
Abucejo-Ladesma, P. Erma
Quiambao, Beatriz P.
Gozum, Lorena
Sombrero, Lydia T.
Romano, Vicente
Riley, Ian
Simoes, Eric A. F.
Acute Respiratory Infections Vaccines (ARIVAC) Consortium
Title Central nervous system infection is an important cause of death in underfives hospitalised with World Health Organization (WHO) defined severe and very severe pneumonia
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
Publication date 2007
Year available 2006
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2006.09.017
Volume 25
Issue 13
Start page 2437
End page 2444
Total pages 8
Place of publication Oxford
Publisher Elsevier
Collection year 2008
Language eng
Subject C1
11 Medical and Health Sciences
Abstract Over 6 years. 1667 children aged 2-59 months admitted for pneumonia [1287 severe and 380 very severe] were studied. The case fatality rate (CFR) in children with severe pneumonia was 2.1% and 14.3% with CNS infection, with very severe pneumonia the CFR was 18.9%, 10.4% in those with hypoxemia and 43.6% with CNS infection. High CFRs were associated with CNS infection and inability to drink/cyanosis. The appropriate management of children with very severe pneumonia should include cerebrospinal fluid examination, oxygen monitoring and possibly ventilated support, suggesting that these are minimal standards of care at the district hospital. (C) 2006 Published by Elsevier Ltd.
Keyword Immunology
Medicine, Research & Experimental
Veterinary Sciences
very severe pneumonia
hypoxemia
meningitis
CNS infection
Bacterial-meningitis
Developing-countries
Children
Diagnosis
Tanzania
Care
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes Available online 20 September 2006

 
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Created: Mon, 18 Feb 2008, 16:53:11 EST