Anaemia and renal function in heart failure due to idiopathic dilated cardiomyopathy

Inglis, Sally C., Stewart, Simon, Papachan, Alexander, Vaghela, Vinesh, Libhaber, Carlos, Veriava, Yosuf and Sliwa, Karen (2007) Anaemia and renal function in heart failure due to idiopathic dilated cardiomyopathy. European Journal of Heart Failure, 9 4: 384-390.


Author Inglis, Sally C.
Stewart, Simon
Papachan, Alexander
Vaghela, Vinesh
Libhaber, Carlos
Veriava, Yosuf
Sliwa, Karen
Title Anaemia and renal function in heart failure due to idiopathic dilated cardiomyopathy
Journal name European Journal of Heart Failure  (ERA 2012 Listed)    (ERA 2010 Rank A)   Check publisher's open access policy
Publication date 2007-01-23
Sub-type Article
DOI 10.1016/j.ejheart.2006.10.013
Volume number 9
Issue number 4
ISSN 1388-9842
Start page 384
End page 390
Total pages 7
Editor K. Swedberg
Place of publication Amsterdam, Netherlands
Publisher Elsevier Science Bv
Collection year 2008
Language eng
Subject 730106 Cardiovascular system and diseases
C1
321003 Cardiology (incl. Cardiovascular Diseases)
Formatted abstract Background: Anaemia and renal dysfunction are common in patients with heart failure (HF). Most studies involve western cohorts with ischaemic aetiology receiving treatment likely to impair renal function.

Aims: To investigate the frequency of anaemia and renal dysfunction and the relationship between the two within a cohort of 163 newly diagnosed Black African idiopathic cardiomyopathy patients prior to commencing HF treatments and compare those findings to those of western HF cohorts.

Methods: Single-centre retrospective analysis. Anaemia defined as haemoglobin concentration <13.0 g/dL for males (n=85) and <12 g/dL for females (n=78). Probable renal dysfunction defined as an estimated glomerular filtration rate of <60 mL/min/1.73 m2, using serum creatinine concentrations.

Results: The mean age was 48±11 years, 52% were male. Overall, 13.5% of patients were anaemic and 11.8% had evidence of renal dysfunction, while 1.2% had both. Renal dysfunction was significantly more common in older patients (mean age 58±13 vs. 47±10 years: p<0.001).

Conclusion: The frequency of anaemia and renal dysfunction in this cohort was lower than that reported in western HF cohorts. These data infer a more limited relationship between HF, anaemia and renal dysfunction in patients without atherothrombotic disease; hence extrapolation of HF data from the western world to other populations should be interpreted cautiously.
Keyword Cardiac & Cardiovascular Systems
heart failure
Africa
cardiomyopathy
renal function
anaemia
Chronic Kidney-disease
Risk-factors
Trial
Mortality
Outcomes
Impact
Death
Insufficiency
Dysfunction
Candesartan
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Mon, 18 Feb 2008, 16:52:34 EST