A model of immune regulation as a consequence of randomized lymphocyte division and death times

Hawkins, E. D., Turner, M. L., Dowling, M. R, van Gend, C. and Hodgkin, P. D. (2007) A model of immune regulation as a consequence of randomized lymphocyte division and death times. Proceedings of The National Academy of Sciences of The United States of America, 104 12: 5032-5037. doi:10.1073/pnas.0700026104


Author Hawkins, E. D.
Turner, M. L.
Dowling, M. R
van Gend, C.
Hodgkin, P. D.
Title A model of immune regulation as a consequence of randomized lymphocyte division and death times
Journal name Proceedings of The National Academy of Sciences of The United States of America   Check publisher's open access policy
ISSN 0027-8424
Publication date 2007-01-01
Sub-type Article (original research)
DOI 10.1073/pnas.0700026104
Open Access Status Not Open Access
Volume 104
Issue 12
Start page 5032
End page 5037
Total pages 6
Place of publication Washington
Publisher Natl Acad Sciences
Collection year 2008
Language eng
Subject C1
Abstract The magnitude of an adaptive immune response is controlled by the interplay of lymphocyte quiescence, proliferation, and apoptosis. How lymphocytes integrate receptor-mediated signals influencing these cell fates is a fundamental question for understanding this complex system. We examined how lymphocytes interleave times to divide and die to develop a mathematical model of lymphocyte growth regulation. This model provides a powerful method for fitting and analyzing fluorescent division tracking data and reveals how summing receptor-mediated kinetic changes can modify the immune response progressively from rapid tolerance induction to strong immunity. An important consequence of our results is that intrinsic variability in otherwise identical cells, usually dismissed as noise, may have evolved to be an essential feature of immune regulation.
Keyword Multidisciplinary Sciences
Stimulatory Factor-i
T-cell Responses
B-cells
Transition-probability
Bystander Activation
Generation Times
Gene-expression
Viral-infection
Cfse Data
Differentiation
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: 2008 Higher Education Research Data Collection
 
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Created: Tue, 19 Feb 2008, 02:44:23 EST