5-HT7, neurogenesis and antidepressants: A promising therapeutic axis for treating depression

Nandam, L. Sanjay, Jhaveri, Dhanisha and Bartlett, Perry (2007) 5-HT7, neurogenesis and antidepressants: A promising therapeutic axis for treating depression. Clinical and Experimental Pharmacology and Physiology, 34 5-6: 546-551. doi:10.1111/j.1440-1681.2007.04608.x


Author Nandam, L. Sanjay
Jhaveri, Dhanisha
Bartlett, Perry
Title 5-HT7, neurogenesis and antidepressants: A promising therapeutic axis for treating depression
Formatted title
5-HT7, neurogenesis and antidepressants: A promising therapeutic axis for treating depression
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 0305-1870
1440-1681
Publication date 2007-05
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1440-1681.2007.04608.x
Volume 34
Issue 5-6
Start page 546
End page 551
Total pages 6
Editor W. P. Anderson
Place of publication Oxford, England
Publisher Blackwell Scientific Publications
Collection year 2008
Language eng
Subject 320704 Cellular Nervous System
730104 Nervous system and disorders
C1
Formatted abstract
1.
There is mounting evidence that a wide range of antidepressants share the common feature of increasing hippocampal neurogenesis. The specificity of this association has suggested that an ability to increase neurogenesis might be a useful paradigm to screen for compounds with antidepressant activity.

2.

The hope of developing better antidepressants has stimulated research into the molecular control of neurogenesis and here we summarize some of the recent findings. We also review recent work that highlights 5-HT7 receptor as a promising molecular target in the treatment of depression.

3.
In summary, it appears that 5-HT7 antagonism is capable of producing diverse antidepressant-like behavioural effects, alters hippocampal neuronal morphology and synergistically regulates hippocampal neurogenesis. © 2007 The Authors.
 
Keyword 5-HT7
Antidepressants
Depression
Hippocampus
Neural precursor
Neurogenesis
Proliferation
Serotonin
Subventricular zone
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
Queensland Brain Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 34 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 18 Feb 2008, 16:43:54 EST