Patterns of somatic mutation in human cancer genomes

Greenman, Christopher, Stephens, Philip, Smith, Raffaella, Dalgliesh, Gillian L., Hunter, Christopher, Bignell, Graham, Davies, Helen, Teague, John, Butler, Adam, Claire Stevens, Edkins, Sarah, O'Meara, Sarah, Vastrik, Imre, Schmidt, Esther E., Avis, Tim, Barthorpe, Syd, Bhamra, Gurpreet, Buck, Gemma, Choudhury, Bhudipa, Cole, Jodie, Cole, Jennifer, Dicks, Ed, Forbes, Simon, Halliday, Kelly, Harrison, Rachel, Hills, Katy, Hinton, Jon, Jenkinson, Andy, Jones, David, Menzies, Andy, Mironenko, Tatiana, Perry, Janet, Raine, Keiran, Richardson, Dave, Shepherd, Rebecca, Small, Alexandra, Tofts, Calli, Varian, Jennifer, Webb, Tony, West, Sofie, Widaa, Sara, Yates, Andy, Cahill, Daniel P., Louis, David N., Goldstraw, Peter, Nicholson, Andrew G., Brasseur, Francis, Looijenga, Leendert, Weber, Barbara L., Chiew, Yoke-Eng, Defazio, Anna, Greaves, Mel F., Green, Anthony R., Campbell, Peter, Birney, Ewan, Easton, Douglas F., Chenevix-Trench, Georgia, Tan, Min-Han, Khoo, Sok Kean, Teh, Bin Tean, Yuen, Siu Tsan, Leung, Suet Yi, Wooster, Richard, Futreal, P. Andrew and Stratton, Michael R. (2007) Patterns of somatic mutation in human cancer genomes. Nature, 446 7132: 153-158. doi:10.1038/nature05610

Author Greenman, Christopher
Stephens, Philip
Smith, Raffaella
Dalgliesh, Gillian L.
Hunter, Christopher
Bignell, Graham
Davies, Helen
Teague, John
Butler, Adam
Claire Stevens
Edkins, Sarah
O'Meara, Sarah
Vastrik, Imre
Schmidt, Esther E.
Avis, Tim
Barthorpe, Syd
Bhamra, Gurpreet
Buck, Gemma
Choudhury, Bhudipa
Cole, Jodie
Cole, Jennifer
Dicks, Ed
Forbes, Simon
Halliday, Kelly
Harrison, Rachel
Hills, Katy
Hinton, Jon
Jenkinson, Andy
Jones, David
Menzies, Andy
Mironenko, Tatiana
Perry, Janet
Raine, Keiran
Richardson, Dave
Shepherd, Rebecca
Small, Alexandra
Tofts, Calli
Varian, Jennifer
Webb, Tony
West, Sofie
Widaa, Sara
Yates, Andy
Cahill, Daniel P.
Louis, David N.
Goldstraw, Peter
Nicholson, Andrew G.
Brasseur, Francis
Looijenga, Leendert
Weber, Barbara L.
Chiew, Yoke-Eng
Defazio, Anna
Greaves, Mel F.
Green, Anthony R.
Campbell, Peter
Birney, Ewan
Easton, Douglas F.
Chenevix-Trench, Georgia
Tan, Min-Han
Khoo, Sok Kean
Teh, Bin Tean
Yuen, Siu Tsan
Leung, Suet Yi
Wooster, Richard
Futreal, P. Andrew
Stratton, Michael R.
Title Patterns of somatic mutation in human cancer genomes
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
Publication date 2007-03-08
Sub-type Article (original research)
DOI 10.1038/nature05610
Volume 446
Issue 7132
Start page 153
End page 158
Total pages 6
Place of publication London, U.K.
Publisher Nature Publishing Group
Language eng
Subject 320000 Medical and Health Sciences
Abstract Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence led us to propose that systematic resequencing of cancer genomes for mutations would lead to the discovery of many additional cancer genes. Here we report more than 1,000 somatic mutations found in 274 megabases (Mb) of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers. There was substantial variation in the number and pattern of mutations in individual cancers reflecting different exposures, DNA repair defects and cellular origins. Most somatic mutations are likely to be 'passengers' that do not contribute to oncogenesis. However, there was evidence for 'driver' mutations contributing to the development of the cancers studied in approximately 120 genes. Systematic sequencing of cancer genomes therefore reveals the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated.
Keyword Multidisciplinary Sciences
Kinase Gene Family
Human Lung-cancer
Colorectal Cancers
Signaling Pathway
Beta Receptor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Mon, 18 Feb 2008, 16:30:11 EST