Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivating Cyclorana alboguttata (Gunther 1867)

Symonds, Beth L., James, Rob S. and Franklin, Craig E. (2007) Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivating Cyclorana alboguttata (Gunther 1867). Journal of Experimental Biology, 210 5: 825-835. doi:10.1242/jeb.02711

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Author Symonds, Beth L.
James, Rob S.
Franklin, Craig E.
Title Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivating Cyclorana alboguttata (Gunther 1867)
Formatted title
Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivating Cyclorana alboguttata (Günther 1867)
Journal name Journal of Experimental Biology   Check publisher's open access policy
ISSN 0022-0949
Publication date 2007
Sub-type Article (original research)
DOI 10.1242/jeb.02711
Open Access Status File (Publisher version)
Volume 210
Issue 5
Start page 825
End page 835
Total pages 11
Editor H. Hoppeler
Place of publication Cambridge, England
Publisher The Company of Biologists Ltd
Collection year 2008
Language eng
Subject C1
270604 Comparative Physiology
780105 Biological sciences
Abstract Prolonged immobilisation or unloading of skeletal muscle causes muscle disuse atrophy, which is characterised by a reduction in muscle cross-sectional area and compromised locomotory function. Animals that enter seasonal dormancy, such as hibernators and aestivators, provide an interesting model for investigating atrophy associated with disuse. Previous research on the amphibian aestivator Cyclorana alboguttata (Gunther 1867) demonstrated an absence of muscle disuse atrophy after 3 months of aestivation, as measured by gastrocnemius muscle contractile properties and locomotor performance. In this study, we aimed to investigate the effect of aestivation on iliofibularis and sartorius muscle morphology and contractile function of C. alboguttata over a longer, more ecologically relevant time-frame of 9 months. We found that whole muscle mass, muscle cross-sectional area, fibre number and proportions of fibre types remained unchanged after prolonged disuse. There was a significant reduction in iliofibularis fibre cross-sectional area (declined by 36% for oxidative fibre area and 39% for glycolytic fibre area) and sartorius fibre density (declined by 44%). Prolonged aestivation had little effect on the isometric properties of the skeletal muscle of C. alboguttata. There was a significant reduction in the isometric contraction times of the relatively slow-twitch iliofibularis muscle, suggesting that the muscle was becoming slower after 9 months of aestivation (time to peak twitch increased by 25%, time from peak twitch to half relaxation increased by 34% and time from last stimulus to half tetanus relation increased by 20%). However, the results of the work-loop analysis clearly demonstrate that, despite changes to muscle morphology and isometric kinetics, the overall contractile performance and power output levels of muscles from 9-month aestivating C. alboguttata are maintained at control levels.
Keyword Biology
aestivation
muscle disuse atrophy
fibre
morphology
contractile properties
locomotion
work loop
Cyclorana alboguttata
Striped Burrowing Frog
Rat Soleus Muscle
Metabolic Depression
Protein-synthesis
Limb Immobilization
Hindlimb Immobilization
Spermophilus-lateralis
Energy-metabolism
Ground-squirrels
Oxidative Stress
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Mon, 18 Feb 2008, 16:28:14 EST