High-level pyrantel resistance in the hookworm Ancylostoma caninum

Kopp, Steven R., Kotze, Andrew C., McCarthy, James S. and Coleman, Glen T. (2007) High-level pyrantel resistance in the hookworm Ancylostoma caninum. Veterinary Parasitology, 143 3-4: 299-304. doi:10.1016/j.vetpar.2006.08.036


Author Kopp, Steven R.
Kotze, Andrew C.
McCarthy, James S.
Coleman, Glen T.
Title High-level pyrantel resistance in the hookworm Ancylostoma caninum
Formatted title
High-level pyrantel resistance in the hookworm Ancylostoma caninum
Journal name Veterinary Parasitology   Check publisher's open access policy
ISSN 0304-4017
Publication date 2007-02
Sub-type Article (original research)
DOI 10.1016/j.vetpar.2006.08.036
Volume 143
Issue 3-4
Start page 299
End page 304
Total pages 6
Editor L. S. Mansfield
C. Genchi
M. A. Taylor
Place of publication Amsterdam
Publisher Elsevier Science Bv
Collection year 2008
Language eng
Subject C1
320405 Medical Parasitology
730101 Infectious diseases
Abstract While anthelmintic resistance is now a widely recognized issue in the livestock industries, its existence within companion animal medicine has been rarely established conclusively. We undertook a placebo-controlled in vivo trial to measure the efficacy of pyrantel embonate against pooled isolates of the hookworm Ancylostoma caninum from Brisbane, Australia. A statistically significant fall in adult worm burden was observed among dogs in the pyrantel treatment group compared to the control dogs (178.0 +/- 24.5 versus 239.7 +/- 14.0; p=0.02), equating to an efficacy of just 25.7% (95% Cl, 15.0-35.1%), as based upon reduction in mean worm burden. Analysis of faecal egg count trends through the course of the study revealed that egg counts rose in both control and pyrantel-treated dogs, with a greater rise observed in the latter group (11.6 +/- 8.3% versus 17.3 +/- 7.6%; p=0.04), despite the decrease in adult worm numbers in this group. Our results indicate that high-level anthelmintic resistance does occur in companion animal medicine, and highlight the need for greater vigilance and more judicious use of anthelmintics in small animal practice. They further indicate that the faecal egg count reduction test needs to be used with caution with this parasite. (c) 2006 Elsevier B.V. All rights reserved.
Keyword Parasitology
Veterinary Sciences
Ancylostoma caninum
dog
pyrantel
resistance
Australia
Egg-production
Dogs
Infection
Selection
Efficacy
Pamoate
Cats
Size
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 32 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 18 Feb 2008, 16:24:00 EST