Does isoprene protect plant membranes from thermal shock? A molecular dynamics study

Siwko, M. E., Marrink, S. J., de Vries, A. H., Kozubek, A., Uiterkamp, A. J. M. S. and Mark, A. E. (2007) Does isoprene protect plant membranes from thermal shock? A molecular dynamics study. Biochimica Et Biophysica Acta-biomembranes, 1768 2: 198-206. doi:10.1016/j.bbamem.2006.09.023


Author Siwko, M. E.
Marrink, S. J.
de Vries, A. H.
Kozubek, A.
Uiterkamp, A. J. M. S.
Mark, A. E.
Title Does isoprene protect plant membranes from thermal shock? A molecular dynamics study
Journal name Biochimica Et Biophysica Acta-biomembranes   Check publisher's open access policy
ISSN 0005-2736
Publication date 2007-01-01
Year available 2006
Sub-type Article (original research)
DOI 10.1016/j.bbamem.2006.09.023
Volume 1768
Issue 2
Start page 198
End page 206
Total pages 9
Place of publication Amsterdam
Publisher Elsevier Science Bv
Collection year 2008
Language eng
Subject 250302 Biological and Medical Chemistry
270402 Plant Physiology
C1
780103 Chemical sciences
780105 Biological sciences
Abstract The question of why plants release isoprene when heat stressed has been continuously debated for more than half a century. In this work we use molecular dynamics simulation techniques to directly investigate the interaction between isoprene and a model phospholipid membrane in atomic detail. It is found that isoprene partitions preferentially in the center of the membrane and in a dose dependent manner enhances the order within the membrane without significantly changing the dynamical properties of the system. At a concentration of 20 mol% isoprene (16 isoprene molecules per 64 lipid molecules) the effect of the addition of isoprene on the membrane order is equivalent to a reduction in temperature of 10 K, rising to a reduction of 30 K at 43 mol% isoprene. The significance of the work is that it provides for the first time direct evidence that isoprene stabilizes lipid membranes and reduces the likelihood of a phospholipid membrane undergoing a heat induced phase transition. Furthermore it provides a clear mechanistic picture as to why plants specifically utilize isoprene for this purpose. (c) 2006 Elsevier B.V All rights reserved.
Keyword Biochemistry & Molecular Biology
Biophysics
isoprene
molecular dynamic
membrane
dimyristoylphosphatidylcholine
simulation
plant
temperature
thermotolerance
Free-volume Properties
Phospholipid-bilayers
Increases Thermotolerance
Lipid-bilayer
Oak Leaves
Simulation
Temperature
Emission
Cholesterol
Hydrocarbons
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Tue, 19 Feb 2008, 02:22:25 EST