Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation

Levick, SP, Loch, DC, Taylor, SM and Janicki, JS (2007) Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation. Journal of Immunology, 178 2: 641-646.


Author Levick, SP
Loch, DC
Taylor, SM
Janicki, JS
Title Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation
Journal name Journal of Immunology   Check publisher's open access policy
ISSN 0022-1767
Publication date 2007
Sub-type Critical review of research, literature review, critical commentary
Volume 178
Issue 2
Start page 641
End page 646
Total pages 6
Editor Rich,R.
Hogan, M.M
Place of publication Bethesda
Publisher Amer Assoc Immunologists
Collection year 2008
Language eng
Subject C1
320599 Pharmacology not elsewhere classified
730102 Immune system and allergy
Abstract An increase in left ventricular collagen (cardiac fibrosis) is a detrimental process that adversely affects heart function. Strong evidence implicates the infiltration of inflammatory cells as a critical part of the process resulting in cardiac fibrosis. Inflammatory cells are capable of releasing arachidonic acid, which may be further metabolized by cyclooxygenase, lipoxygenase, and cytochrome P450 monooxygenase enzymes to biologically active products, including PGs, leukotrienes, epoxyeicosatrienoic acids, and hydroxyeicosatetraenoic acids. Some of these products have profibrotic properties and may represent a pathway by which inflammatory cells initiate and mediate the development of cardiac fibrosis. In this study, we critically review, the current literature on the potential link between this pathway and cardiac fibrosis.
Keyword Immunology
Secretory Phospholipase A(2)
Acute Myocardial-infarction
Monocyte Chemoattractant Protein-1
Congestive-heart-failure
Nitric-oxide Synthesis
Murine Mast-cells
Alveolar Macrophages
20-hydroxyeicosatetraenoic Acid
Dilated Cardiomyopathy
P388d(1) Macrophages
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes This document is a journal review.

 
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Created: Mon, 18 Feb 2008, 16:01:07 EST