A comparison of pathomolecular markers of fibrosis and morphology in kidney from autopsies of African Americans and whites

Pat, Betty, Hughson, Michael D., Nicol, Jennifer L., Hoy, Wendy E and Gobe, Glenda C. (2007) A comparison of pathomolecular markers of fibrosis and morphology in kidney from autopsies of African Americans and whites. Virchows Archiv, 450 1: 41-50.


Author Pat, Betty
Hughson, Michael D.
Nicol, Jennifer L.
Hoy, Wendy E
Gobe, Glenda C.
Title A comparison of pathomolecular markers of fibrosis and morphology in kidney from autopsies of African Americans and whites
Journal name Virchows Archiv   Check publisher's open access policy
ISSN 0945-6317
Publication date 2007-01
Year available 2006
Sub-type Article (original research)
DOI 10.1007/s00428-006-0335-x
Volume 450
Issue 1
Start page 41
End page 50
Total pages 10
Editor H. K. Hoefler
M. Dietel
P. Bedosa
V.Eusebi
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2008
Language eng
Subject C1
321012 Nephrology and Urology
730115 Urogenital system and disorders
Abstract African Americans have an increased incidence of chronic kidney disease (CKD) due to hypertension and arteriosclerosis and increased death due to coronary artery disease, compared with whites. The pathogenesis of CKD involves the increased presence and activation of myofibroblasts and macrophages, promotion of tubulointerstitial fibrosis, and effects of tubulointerstitial cell mitosis and apoptosis. We hypothesized that increased risk of hypertensive vascular disease may be identified by renal pathomolecular markers that are associated with progressive CKD. Renal sections were available from 50 autopsies of 33 African Americans (55% males) and 17 whites (76% males) undergoing forensic autopsy for unexpected death. Sclerotic glomeruli, severity of cortical fibrosis, and renal arterioloselerosis, total glomerular number (N-glom), average glomerular volume (V-glom), birth weights, and blood pressure were known. Presence and locality of markers for myofibroblasts (alpha-SMA), macrophages (CD68), collagen, pro-fibrotic transforming growth factor-beta1 were scored in renal autopsies, and tubulointerstitial apoptosis was recorded. The results demonstrated a strong positive correlation between age, cortical fibrosis and alpha-SMA (p < 0.05), and between CD68 and hypertension and coronary artery disease (p < 0.05). The findings confirm the role of myofibroblasts and macrophages in pathogenesis of human CKD. However, the markers showed no significant relationships to V-glom, N-glom, birth weight, or race.
Keyword Pathology
chronic renal failure
fibrosis
molecular markers
apoptosis
growth factor
myofibroblast
macrophage
Stage Renal-disease
Glomerular Size
Tubulointerstitial Fibrosis
Cardiovascular-disease
Birth-weight
Hypertension
Myofibroblasts
Apoptosis
Life
Glomerulonephritis
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes Claimed in 2008 - published online 2006

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Fri, 08 Feb 2008, 15:06:10 EST by Brenda Mason on behalf of Medicine - Royal Brisbane and Women's Hospital