Changes in markers of muscle damage, inflammation and HSP70 after an Ironman triathlon race

Suzuki, Katsuhiko, Peake, Jonathan, Nosaka, Kazunori, Okutsu, Mitsuharu, Abbiss, Chris R., Surriano, Rob, Bishop, David, Quod, Marc J., Lee, Hamilton, Martin, David T. and Laursen, Paul B. (2006) Changes in markers of muscle damage, inflammation and HSP70 after an Ironman triathlon race. European Journal of Applied Physiology, 98 6: 525-534. doi:10.1007/s00421-006-0296-4


Author Suzuki, Katsuhiko
Peake, Jonathan
Nosaka, Kazunori
Okutsu, Mitsuharu
Abbiss, Chris R.
Surriano, Rob
Bishop, David
Quod, Marc J.
Lee, Hamilton
Martin, David T.
Laursen, Paul B.
Title Changes in markers of muscle damage, inflammation and HSP70 after an Ironman triathlon race
Journal name European Journal of Applied Physiology   Check publisher's open access policy
ISSN 1439-6319
Publication date 2006-12
Sub-type Article (original research)
DOI 10.1007/s00421-006-0296-4
Volume 98
Issue 6
Start page 525
End page 534
Total pages 10
Place of publication New York, N.Y. U.S.A.
Publisher Springer
Language eng
Subject 1106 Human Movement and Sports Science
Abstract We investigated the effects of an Ironman triathlon race on markers of muscle damage, inflammation and heat shock protein 70 (HSP70). Nine well-trained male triathletes (mean +/- SD age 34 +/- 5 years; VO2peak 66.4 ml kg(-1) min(-1)) participated in the 2004 Western Australia Ironman triathlon race (3.8 km swim, 180 km cycle, 42.2 km run). We assessed jump height, muscle strength and soreness, and collected venous blood samples 2 days before the race, within 30 min and 14-20 h after the race. Plasma samples were analysed for muscle proteins, acute phase proteins, cytokines, heat shock protein 70 (HSP70), and clinical biochemical variables related to dehydration, haemolysis, liver and renal functions. Muscular strength and jump height decreased significantly (P < 0.05) after the race, whereas muscle soreness and the plasma concentrations of muscle proteins increased. The cytokines interleukin (IL)-1 receptor antagonist, IL-6 and IL-10, and HSP70 increased markedly after the race, while IL-12p40 and granulocyte colony-stimulating factor (G-CSF) were also elevated. IL-4, IL-1 beta and tumour necrosis factor-alpha did not change significantly, despite elevated C-reactive protein and serum amyloid protein A on the day after the race. Plasma creatinine, uric acid and total bilirubin concentrations and gamma-glutamyl transferase activity also changed after the race. In conclusion, despite evidence of muscle damage and an acute phase response after the race, the pro-inflammatory cytokine response was minimal and anti-inflammatory cytokines were induced. HSP70 is released into the circulation as a function of exercise duration.
Keyword Physiology
Sport Sciences
ultraendurance exercise
acute phase proteins
cytokines
heat shock protein 70
systemic stress
Skeletal-muscle
Interleukin-6 Release
Exhaustive Exercise
Immune-response
Distance
Humans
Endotoxemia
Performance
Cytokines
Balance
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Human Movement and Nutrition Sciences Publications
 
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Created: Fri, 25 Jan 2008, 16:59:23 EST