Birth of a metabolic gene cluster in yeast by adaptive gene relocation

Wong, S and Wolfe, KH (2005) Birth of a metabolic gene cluster in yeast by adaptive gene relocation. Nature Genetics, 37 7: 777-782.


Author Wong, S
Wolfe, KH
Title Birth of a metabolic gene cluster in yeast by adaptive gene relocation
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2005
Sub-type Article (original research)
DOI 10.1038/ng1584
Volume 37
Issue 7
Start page 777
End page 782
Total pages 6
Place of publication New York
Publisher Nature Publishing Group
Language eng
Abstract Although most eukaryotic genomes lack operons, they contain some physical clusters of genes that are related in function despite being unrelated in sequence(1-5). How these clusters are formed during evolution is unknown. The DAL cluster is the largest metabolic gene cluster in yeast and consists of six adjacent genes encoding proteins that enable Saccharomyces cerevisiae to use allantoin as a nitrogen source(6). We show here that the DAL cluster was assembled, quite recently in evolutionary terms, through a set of genomic rearrangements that happened almost simultaneously. Six of the eight genes involved in allantoin degradation, which were previously scattered around the genome, became relocated to a single subtelomeric site in an ancestor of S. cerevisiae and Saccharomyces castellii. These genomic rearrangements coincided with a biochemical reorganization of the purine degradation pathway, which switched to importing allantoin instead of urate. This change eliminated urate oxidase, one of several oxygen- consuming enzymes that were lost by yeasts that can grow vigorously in anaerobic conditions. The DAL cluster is located in a domain of modified chromatin involving both H2A. Z histone exchange and Hst1- Sum1 - mediated histone deacetylation, and it may be a coadapted gene complex formed by epistatic selection.
Keyword Genetics & Heredity
Saccharomyces-cerevisiae
Natural-selection
Genome
Recruitment
Expression
Linkage
Order
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Fri, 25 Jan 2008, 16:35:38 EST