Elevated erythrocyte CDP-choline levels associated with beta-thalassaemia in patients with transfusion independent anaemia

Laurence, A. D., Layton, M., Duley, J. A. and Simmonds, H. A. (2004) Elevated erythrocyte CDP-choline levels associated with beta-thalassaemia in patients with transfusion independent anaemia. Nucleosides Nucleotides & Nucleic Acids, 23 8-9: 1265-1267. doi:10.1081/NCN-200027535


Author Laurence, A. D.
Layton, M.
Duley, J. A.
Simmonds, H. A.
Title Elevated erythrocyte CDP-choline levels associated with beta-thalassaemia in patients with transfusion independent anaemia
Journal name Nucleosides Nucleotides & Nucleic Acids   Check publisher's open access policy
ISSN 1525-7770
Publication date 2004-12
Sub-type Article (original research)
DOI 10.1081/NCN-200027535
Volume 23
Issue 8-9
Start page 1265
End page 1267
Total pages 3
Place of publication New York, N.Y. U.S.A.
Publisher Marcel Dekker Inc
Language eng
Subject 1115 Pharmacology and Pharmaceutical Sciences
Abstract The accumulation of CDP-ethanolamine as well as CDP-choline in a small cohort of patients with normal UMPH1 and no defined cause for their anaemia suggested a defect in both phosphotransferases. Here we report 10 patients with transfusion independent beta-thalassaemia; 8 being pure heterozygotes and 2 heterozygotes also for Hb E. Mean CDP-choline (86.squaresquaresquare +/- 48 muM) and CDP-ethanolamine (34.6 muM 34.5 muM), mean control <3 muM. Elevated CDP-choline in patients with no defined cause for their haemolytic anaemia was previously suggested as a possible indicator of CDP-choline phosphotransferase deficiency. Here we associate it with transfusion independent beta-thalassaemia.
Keyword Biochemistry & Molecular Biology
beta-thalassaemia trait
CDP-choline
CDP-ethanolamine
CDP-choline phosphotransferase
haemolytic anaemia
basophilic stippling
Accumulation
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Pharmacy Publications
 
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Created: Fri, 25 Jan 2008, 16:23:58 EST