Transient retention of endochondral cartilaginous matrix with bisphosphonate treatment in a long-term rabbit model of distraction osteogpnesis

Smith, Elisabeth J., McEvoy, Anthony, Little, David G., Baldock, Paul A., Eisman, John A . and Gardiner, Edith M. (2004) Transient retention of endochondral cartilaginous matrix with bisphosphonate treatment in a long-term rabbit model of distraction osteogpnesis. Journal of Bone And Mineral Research, 19 10: 1698-1705. doi:10.1359/JBMR.040709


Author Smith, Elisabeth J.
McEvoy, Anthony
Little, David G.
Baldock, Paul A.
Eisman, John A .
Gardiner, Edith M.
Title Transient retention of endochondral cartilaginous matrix with bisphosphonate treatment in a long-term rabbit model of distraction osteogpnesis
Journal name Journal of Bone And Mineral Research   Check publisher's open access policy
ISSN 0884-0431
Publication date 2004-10
Sub-type Article (original research)
DOI 10.1359/JBMR.040709
Volume 19
Issue 10
Start page 1698
End page 1705
Total pages 8
Place of publication Washington, D. C., U.S.A.
Publisher American Society for Bone & Mineral Research
Language eng
Subject 0601 Biochemistry and Cell Biology
Abstract Bisphosphonates induce major increases in strength of callus in distraction osteogenesis in the short term. Poor understanding of the underlying mechanism, however, raises concerns about long-term consequences. In this long-term study in 32 rabbits, zoledronic acid transiently increased trabeculae by delayed temporal progression of endochondral bone remodeling but did not prevent radiographic completion of hope repair.
Keyword Endocrinology & Metabolism
distraction osteogenesis
bisphosphonate
endochondral cartilaginous matrix
rabbit
Bone
Fracture
Osteogenesis
Rats
Chondrocytes
Clodronate
Proliferation
Osteoporosis
Resorption
Increases
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 32 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 32 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 25 Jan 2008, 16:21:22 EST