Human leukocyte antigen class II alleles influence levels of antibodies to the Plasmodium falciparum asexual-stage apical membrane antigen 1 but not to merozoite surface antigen 2 and merozoite surface protein 1

Johnson, Armead H., Leke, Rose G. F., Mendell, Nancy R., Shon, Dewon, Sub, Young J., Bomba-Nkolo, Dennis, Tchinda, Viviane, Kouontchou, Samuel, Thuita, Lucy W., Van der Wel, Anne Marie, Thomas, Alan, Stowers, Anthony, Saul, Allan, Zhou, Ainog, Taylor, Diane W. and Quakyi, Isabella A. (2004) Human leukocyte antigen class II alleles influence levels of antibodies to the Plasmodium falciparum asexual-stage apical membrane antigen 1 but not to merozoite surface antigen 2 and merozoite surface protein 1. Infection And Immunity, 72 5: 2762-2771. doi:10.1128/IAI.72.5.2762-2771.2004

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Author Johnson, Armead H.
Leke, Rose G. F.
Mendell, Nancy R.
Shon, Dewon
Sub, Young J.
Bomba-Nkolo, Dennis
Tchinda, Viviane
Kouontchou, Samuel
Thuita, Lucy W.
Van der Wel, Anne Marie
Thomas, Alan
Stowers, Anthony
Saul, Allan
Zhou, Ainog
Taylor, Diane W.
Quakyi, Isabella A.
Title Human leukocyte antigen class II alleles influence levels of antibodies to the Plasmodium falciparum asexual-stage apical membrane antigen 1 but not to merozoite surface antigen 2 and merozoite surface protein 1
Formatted title
Human leukocyte antigen class II alleles influence levels of antibodies to the Plasmodium falciparum asexual-stage apical membrane antigen 1 but not to merozoite surface antigen 2 and merozoite surface protein 1
Journal name Infection And Immunity   Check publisher's open access policy
ISSN 1098-5522
1070-6313
Publication date 2004-05
Sub-type Article (original research)
DOI 10.1128/IAI.72.5.2762-2771.2004
Open Access Status File (Publisher version)
Volume 72
Issue 5
Start page 2762
End page 2771
Total pages 10
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract The apical membrane antigen 1 (AMA1), merozoite surface antigen 2 (MSA2), and merozoite surface protein 1 (MSP1) are asexual-stage proteins currently being evaluated for inclusion in a vaccine for Plasmodium falciparum. Accordingly, it is important to understand factors that control antibody responses to these antigens. Antibody levels in plasma from residents of Etoa, Cameroon, between the ages of 5 and 70 years, were determined using recombinant AMA1, MSA2, and the N-terminal region of MSP1 (MSP1-190L). In addition, antibody responses to four variants of the C-terminal region of MSP1 (MSP1(19)) were assessed. Results showed that all individuals produced antibodies to AMA1, MSA2, and MSP1-190L; however, a proportion of individuals never produced antibodies to the MSP1(19) variants, although the percentage of nonresponders decreased with age. The influence of age and human leukocyte antigen (HLA)-DRB1/DQB1 alleles on antibody levels was evaluated using two-way analysis of variance. Age was correlated with levels of antibodies to AMA1 and MSP1(19) but not with levels of antibodies to MSA2 and MSP1-190L. No association was found between a single HLA allele and levels of antibodies to MSA2, MSP1-190L, or any of the MSP1(19) variants. However, individuals positive for DRB1*1201 had higher levels of antibodies to the variant of recombinant AMA1 tested than did individuals of all other HLA types. Since the effect was seen across all age groups, HLA influenced the level but not the rate of antibody acquisition. This association for AMA1, combined with the previously reported association between HLA class II alleles and levels of antibodies to rhoptry-associated protein 1 (RAP1) and RAP2, indicates that HLA influences the levels of antibodies to three of the five vaccine candidate antigens that we have evaluated.
Keyword Immunology
Infectious Diseases
Inhibit Parasite Growth
Humoral Immune-response
C-terminal Fragment
Malaria Morbidity
Monoclonal-antibodies
Clinical Immunity
Cell Invasion
Full-length
Hla-dr
Vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 25 Jan 2008, 16:12:02 EST