Relationship of non-LDL-bound apo(a), urinary apo(a) fragments and plasma Lp(a) in patients with impaired renal function

Cauza, Edmund, Kletzmaier, Josef, Bodlaj, Gert, Dunkyl, Attila, Herrmann, Wolfgang and Kostner, Karam (2003) Relationship of non-LDL-bound apo(a), urinary apo(a) fragments and plasma Lp(a) in patients with impaired renal function. Nephrology Dialysis Transplantation, 18 8: 1568-1572. doi:10.1093/ndt/gfg181


Author Cauza, Edmund
Kletzmaier, Josef
Bodlaj, Gert
Dunkyl, Attila
Herrmann, Wolfgang
Kostner, Karam
Title Relationship of non-LDL-bound apo(a), urinary apo(a) fragments and plasma Lp(a) in patients with impaired renal function
Journal name Nephrology Dialysis Transplantation   Check publisher's open access policy
ISSN 0931-0509
Publication date 2003-01-01
Sub-type Article (original research)
DOI 10.1093/ndt/gfg181
Volume 18
Issue 8
Start page 1568
End page 1572
Total pages 5
Editor Tilman Drueke
Place of publication United Kingdom
Publisher Oxford University Press
Collection year 2003
Language eng
Subject C1
321012 Nephrology and Urology
730118 Organs, diseases and abnormal conditions not elsewhere classified
Formatted abstract
Background. Plasma lipoprotein (a) [Lp(a)] has been shown to be a risk factor for atherosclerosis in numerous studies. However, the catabolism of this lipoprotein is not very clear. We and others have shown that Lp(a) is excreted into urine in the form of fragments. Lp(a) has also been shown to exist in a low-density non-lipoprotein (LDL)-bound form. Since Lp(a) is increased in all forms of kidney disease with reduced excretory kidney function and decreased excretion of apo(a) fragments could be partially responsible for this increase, we investigated the relationship of non-LDL-bound apo(a), urinary apo(a) fragments and plasma Lp(a) in patients with impaired renal function.

Methods.
Plasma Lp(a), non-LDL-bound apo(a) and urinary apo(a) fragments were measured in 55 kidney disease patients (28 males and 27 females) and matched controls.

Results. Plasma Lp(a) and non-LDL-bound apo(a) were increased in patients, whereas urinary apo(a) was decreased, especially in patients with a creatinine clearance < 70 ml/min. There was a significant correlation between plasma Lp(a) and non-LDL-bound apo(a) in patients and controls.

Conclusion. We conclude that decreased urinary apo(a) excretion could be one possible mechanism of increased plasma Lp(a) and non-LDL-bound apo(a) in patients with decreased kidney function.
Keyword Transplantation
Urology & Nephrology
lipoprotein (a)
non-LDL-bound apo(a)
renal function
urinary apo(a)
Coronary-artery Disease
Lipoprotein(a)
Serum
Apolipoprotein(a)
Excretion
Wall
Risk
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Sat, 26 Jan 2008, 01:59:01 EST