Future directions in substance dependence research

Nutt, D., Lingford-Hughes, A. and Daglish, M. (2003). Future directions in substance dependence research. In: Journal of Neural Transmission Supplementum. 5th Neuropsychiatry Symposium of the European Institute of Healthcare, Barcelona, Spain, (95-103). 2002.

Author Nutt, D.
Lingford-Hughes, A.
Daglish, M.
Title of paper Future directions in substance dependence research
Conference name 5th Neuropsychiatry Symposium of the European Institute of Healthcare
Conference location Barcelona, Spain
Conference dates 2002
Proceedings title Journal of Neural Transmission Supplementum   Check publisher's open access policy
Journal name Journal of Neural Transmission-Supplement   Check publisher's open access policy
Place of Publication Wien ; New York
Publisher Springer
Publication Year 2003
Sub-type Fully published paper
ISBN 3211839038
ISSN 0303-6995
Issue Supplement 64
Start page 95
End page 103
Total pages 9
Language eng
Abstract/Summary Substance dependence is a major health problem but increasing understanding of its neurobiology is likely to lead to improved prevention and treatment. Fundamental aspects of dependence include tolerance and withdrawal and the fact that the drug becomes the centre of the addict's world. Neuroimaging has been key in defining underlying neurobiological mechanisms. The activity in particular brain regions has been shown to be altered in addiction. These include the anterior cingulate which is involved in emotional salience and the orbitofrontal cortex, involved in impulse control. Dopamine is the key neurotransmitter since most abused drugs increase its levels, and many pharmacotherapies have targeted this system. The opiate system is also key in mediating the pleasurable effects of some drugs such as alcohol by increasing dopamine levels. The GABA and glutamate systems mediate many of the other effects of alcohol. As the neurobiology of different components of addiction become evident, pharmacological approaches involve exploiting our new understanding which will likely lead to improved treatments.
Subjects 110319 Psychiatry (incl. Psychotherapy)
Keyword Neurosciences
Obsessive-compulsive Disorder
Orbitofrontal Cortex
Human Brain
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Unknown

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Created: Fri, 25 Jan 2008, 15:57:37 EST