A global perspective on cadmium pollution and toxicity in non-occupationally exposed population

Satarug, Soisungwan, Baker, Jason R., Urbenjapol, Supanee, Haswell-Elkins, Melissa, Reilly, Paul E. B., Williams, David J. and Moore, Michael R. (2003) A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicology Letters, 137 1-2: 65-83.


Author Satarug, Soisungwan
Baker, Jason R.
Urbenjapol, Supanee
Haswell-Elkins, Melissa
Reilly, Paul E. B.
Williams, David J.
Moore, Michael R.
Title A global perspective on cadmium pollution and toxicity in non-occupationally exposed population
Journal name Toxicology Letters   Check publisher's open access policy
ISSN 0378-4274
Publication date 2003-01-31
Sub-type Article (original research)
DOI 10.1016/S0378-4274(02)00381-8
Volume 137
Issue 1-2
Start page 65
End page 83
Total pages 19
Place of publication Clare
Publisher Elsevier Sci Ireland Ltd
Language eng
Subject 11 Medical and Health Sciences
Abstract Cadmium is a non-essential element that has high rates of soil to plant transference compared with other nonessential elements, and certain plant species accumulate large amounts of cadmium from low cadmium content soils. In this paper, levels of cadmium found in major food groups are highlighted together with cadmium levels found in liver and kidney samples from non-occupationally exposed populations. Data on human kidney cadmium levels identified recently, including the study in our own laboratory, are compared with older studies. Human-tissue cadmium contents showed large variations among individuals, but sources of the variation remain unknown. Exposure levels of 30-50 mug per day have been estimated for adults and these levels have been linked to increased risk of bone fracture, cancer, kidney dysfunction and hypertension. Increased mortality was found among individuals showing signs of cadmium renal toxicity compared with those without such signs, suggesting that renal toxicity may be an early warning of complications, sub-clinical or clinical morbidity. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Keyword Toxicology
cadmium
renal toxicity
environmental pollution
heavy metals
mortality
hypertension
Japanese General-population
Intestinal Iron-absorption
Dose-response Relationship
Renal Tubular Dysfunction
Middle-aged Women
Urinary Cadmium
Environmental Cadmium
Dietary-intake
Kidney Cortex
Metallothionein Levels
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
National Research Centre for Environmental Toxicology Publications
 
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