Regional differences in sympathetic purinergic transmission along the length of the mouse vas deferens

Knight, D., D'Arbe, M., Liang, S., Phillips, W. D. and Lavidis, N. A. (2003) Regional differences in sympathetic purinergic transmission along the length of the mouse vas deferens. Synapse, 47 3: 225-235. doi:10.1002/syn.10119


Author Knight, D.
D'Arbe, M.
Liang, S.
Phillips, W. D.
Lavidis, N. A.
Title Regional differences in sympathetic purinergic transmission along the length of the mouse vas deferens
Journal name Synapse   Check publisher's open access policy
ISSN 0887-4476
Publication date 2003-03-01
Sub-type Article (original research)
DOI 10.1002/syn.10119
Volume 47
Issue 3
Start page 225
End page 235
Total pages 11
Place of publication New York
Publisher Wiley-liss
Language eng
Subject 06 Biological Sciences
0608 Zoology
060807 Animal Structure and Function
Abstract Contraction of the smooth muscle in the mouse vas deferens is elicited by sympathetic nerves releasing at least two neurotransmitters, adenosine triphosphate (ATP) and noradrenaline (NA). Several studies have indicated the presence of regional variation in the purinergic and noradrenergic contributions to sympathetic nerve-evoked contractions in rodent vasa deferentia. We examined the relative contribution of ATP and NA to neurotransmission and contraction at the prostatic and epididymal ends of the mouse vas deferens. The success rate of recording excitatory junction currents (EJCs, extracellular indication of ATP release) from varicosities at the prostatic end of the vas deferens was eight times greater than for varicosities located at the epididymal end. Both regions of the vas deferens responded similarly to focal application of NA and ATP. Furthermore, the relative density and distribution of P2X(1)-receptor mRNA and anti-P2X(1) immunostaining did not differ between the two regions. Our results suggest that most varicosities located at the epididymal end of the vas deferens are releasing an insufficient amount of ATP to evoke detectable EJCs. (C) 2002 Wiley-Liss, Inc.
Keyword Neurosciences
prostatic
epididymal
P2X(1) purinoceptors
sympathetic varicosities
Rat Tail Artery
Transmitter Release
Smooth-muscle
Guinea-pig
Noradrenaline Release
Nerve Varicosities
Field Stimulation
P2x(1) Receptors
Atp
Secretion
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Sat, 26 Jan 2008, 01:49:16 EST