Body size and breast cancer risk: Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Lahmann, Petra H., Hoffmann, Kurt, Allen, Naomi, van Gils, Carla H., Khaw, Kay-Tee, Tehard, Bertrand, Berrino, Franco, Tjoenneland, Anne, Biggard, Janne, Olsen, Anja, Overvad, Kim, Clavel-Chapelon, Françoise, Nagel, Gabriele, Boeing, Heiner, Trichopoulos, Dimitrios, Economou, George, Bellos, George, Palli, Domenico, Tumino, Rosario, Panico, Salvatore, Sacerdote, Carlotta, Krogh, Vittorio, Peeters, Petra H.M., Bas Bueno-de-Mesquita, H., Lund, Eiliv, Ardanaz, Eva, Amiano, Pilar, Pera, Guillem, Quirós, José R. and Martínez, Carmen (2004) Body size and breast cancer risk: Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC). International Journal of Cancer, 111 5: 762-771. doi:10.1002/ijc.20315

Author Lahmann, Petra H.
Hoffmann, Kurt
Allen, Naomi
van Gils, Carla H.
Khaw, Kay-Tee
Tehard, Bertrand
Berrino, Franco
Tjoenneland, Anne
Biggard, Janne
Olsen, Anja
Overvad, Kim
Clavel-Chapelon, Françoise
Nagel, Gabriele
Boeing, Heiner
Trichopoulos, Dimitrios
Economou, George
Bellos, George
Palli, Domenico
Tumino, Rosario
Panico, Salvatore
Sacerdote, Carlotta
Krogh, Vittorio
Peeters, Petra H.M.
Bas Bueno-de-Mesquita, H.
Lund, Eiliv
Ardanaz, Eva
Amiano, Pilar
Pera, Guillem
Quirós, José R.
Martínez, Carmen
Title Body size and breast cancer risk: Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 0020-7136
Publication date 2004-09-20
Year available 2004
Sub-type Article (original research)
DOI 10.1002/ijc.20315
Volume 111
Issue 5
Start page 762
End page 771
Total pages 10
Place of publication New York
Publisher Wiley-Liss
Language eng
Subject 321202 Epidemiology
1117 Public Health and Health Services
Abstract The evidence for anthropometric factors influencing breast cancer risk is accumulating, but uncertainties remain concerning the role of fat distribution and potential effect modifiers. We used data from 73,542 premenopausal and 103,344 postmenopausal women from 9 European countries, taking part in the EPIC study. RRs from Cox regression models were calculated, using measured height, weight, BMI and waist and hip circumferences; categorized by cohort wide quintiles; and expressed as continuous variables, adjusted for study center, age and other risk factors. During 4.7 years of follow-up, 1,879 incident invasive breast cancers were identified. In postmenopausal women, current HRT modified the body size-breast cancer association. Among nonusers, weight, BMI and hip circumference were positively associated with breast cancer risk (all P-trend less than or equal to 0.002); obese women (BMI > 30) had a 31% excess risk compared to women with BMI < 25. Among HRT users, body measures were inversely but nonsignificantly associated with breast cancer. Excess breast cancer risk with HRT was particularly evident among lean women. Pooled RRs per height increment of 5 cm were 1.05 (95% CI 1.00-1.16) in premenopausal and 1.10 (95% CI 1.05-1.16) in postmenopausal women. Among premenopausal women, hip circumference was the only other measure significantly related to breast cancer (P-trend = 0.03), after accounting for BMI. In postmenopausal women not taking exogenous hormones, general obesity is a significant predictor of breast cancer, while abdominal fat assessed as waist-hip ratio or waist circumference was not related to excess risk when adjusted for BMI. Among premenopausal women, weight and BMI showed nonsignificant inverse associations with breast cancer.
Keyword Oncology
breast neoplasm
fat distribution
body weight
hormone replacement therapy
Hormone-replacement Therapy
Postmenopausal Women
Fat Distribution
Mass Index
Q-Index Code C1
Additional Notes All Authors: Petra H. Lahmann , Kurt Hoffmann , Naomi Allen, Carla H. van Gils, Kay-Tee Khaw, Bertrand Tehard, Franco Berrino, Anne Tjønneland, Janne Bigaard, Anja Olsen, Kim Overvad, Françoise Clavel-Chapelon, Gabriele Nagel, Heiner Boeing Dimitrios Trichopoulos, George Economou, George Bellos, Domenico Palli, Rosario Tumino, Salvatore Panico, Carlotta Sacerdote, Vittorio Krogh, Petra H.M. Peeters, H. Bas Bueno-de-Mesquita, Eiliv Lund, Eva Ardanaz, Pilar Amiano, Guillem Pera, José R. Quirós, Carmen Martínez, María J. Tormo, Elisabet Wirfält, Göran Berglund, Göran Hallmans, Timothy J. Key, Gillian Reeves, Sheila Bingham, Teresa Norat, Carine Biessy, Rudolf Kaaks, Elio Riboli

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 289 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 02 Jan 2008, 13:30:01 EST by Thelma Whitbourne on behalf of School of Public Health