A Dde-based carboxy linker for solid-phase synthesis

Chhabra, S. R., Parekh, H., Khan, A., Bycroft, B. and Kellam, B. (2001) A Dde-based carboxy linker for solid-phase synthesis. Tetrahedron Letters, 42 11: 2189-2192.


Author Chhabra, S. R.
Parekh, H.
Khan, A.
Bycroft, B.
Kellam, B.
Title A Dde-based carboxy linker for solid-phase synthesis
Journal name Tetrahedron Letters   Check publisher's open access policy
ISSN 0040-4039
Publication date 2001-03-11
Sub-type Article (original research)
DOI 10.1016/S0040-4039(01)00101-0
Volume 42
Issue 11
Start page 2189
End page 2192
Total pages 4
Editor Chandrasekaran, S.
Ganem, B.
Guo-Qiang, Lin
Thomas, E.J.
Wood, J.
Yamamoto, Y.
Zard, S.Z.
Place of publication Oxford
Publisher Pergamon Press
Language eng
Subject 320500 Pharmacology and Pharmaceutical Sciences
250301 Organic Chemical Synthesis
Abstract The Dde-derived carboxy protecting group, 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester (ODmab) has been developed into a carboxy functional linker. The stability of the linker to standard acid and base conditions employed in Fmoc/tBu SPPS has been demonstrated and its utility illustrated by the construction of model peptides, Leu-enkephalin and Human Angiotensin II.
Keyword carboxylic acids
linkers
solid-phase synthesis
supported reagents/reactions
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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