Computational Fluid Dynamics Investigation of a Cavity Micro-Bioreactor

Tan, W. L., Thouas, G. A., Thompson, M. C. and Hourigan, K. (2007). Computational Fluid Dynamics Investigation of a Cavity Micro-Bioreactor. In: Peter Jacobs, Tim McIntyre, Matthew Cleary, David Buttsworth, David Mee, Rose Clements, Richard Morgan and Charles Lemckert, 16th Australasian Fluid Mechanics Conference (AFMC). 16th Australasian Fluid Mechanics Conference (AFMC), Gold Coast, Queensland, Australia, (346-352). 3-7 December, 2007.

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Author Tan, W. L.
Thouas, G. A.
Thompson, M. C.
Hourigan, K.
Title of paper Computational Fluid Dynamics Investigation of a Cavity Micro-Bioreactor
Conference name 16th Australasian Fluid Mechanics Conference (AFMC)
Conference location Gold Coast, Queensland, Australia
Conference dates 3-7 December, 2007
Proceedings title 16th Australasian Fluid Mechanics Conference (AFMC)
Place of Publication Brisbane, Australia
Publisher School of Engineering, The University of Queensland
Publication Year 2007
Year available 2007
Sub-type Fully published paper
ISBN 978-1-864998-94-8
Editor Peter Jacobs
Tim McIntyre
Matthew Cleary
David Buttsworth
David Mee
Rose Clements
Richard Morgan
Charles Lemckert
Start page 346
End page 352
Total pages 7
Collection year 2007
Language eng
Abstract/Summary In this paper, cavity aspect ratios and fluid inflow velocities of an idealized perfusion cavity micro-bioreactor for embryos were examined using computational fluid dynamics simulations. Changes to aspect ratios led to altered flow structures and concentration distributions of fluid solutes within the cavity. When cavity aspect ratios were decreased to less than unity, the resulting transport of solutes was impaired, but relatively low shear stresses were found to be imposed on the enclosed embryo. Conversely, when aspect ratios were greater to than unity, more efficient solute transport was observed, however detrimentally increased levels of shear stresses were imposed on the embryo. Variation in solute concentrations within the cavity became very small as cavity aspect ratios were increased to larger than four. Changes of inflow velocities of fluid (culture medium) into the bioreactor were also found to have substantial impact on the flow structures and solute concentration distributions within the cavity. With low inflow velocities, fluid movement in the bioreactor were dominated by diffusion, with impaired solute transport within the cavity and relatively low shear stresses imposed on the embryo. Conversely, high inflow velocities caused fluid flow in the bioreactor to be dominated by advection, promoting solute transport but leading to relatively high shear stresses. The flow Peclet number (Pe) can be used to distinguish whether the flow is advection dominant (Pe > 1) or diffusion dominant (Pe < 1). Overall, both parametric studies provided information that would be highly useful to the design of an optimized perfusion micro-bioreactor for early embryos. For example, one could select the optimum cavity shape to breed certain types of embryo based on the findings from the cavity aspect ratio study or make an informed choice in setting the suitable flow rates based on the findings from the fluid inflow velocity study.
Subjects 290501 Mechanical Engineering
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Collection: 16th Australasian Fluid Mechanics Conference
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Created: Wed, 19 Dec 2007, 09:35:13 EST by Laura McTaggart on behalf of School of Engineering