New cyclic peptides with cytotoxic activity from the ascidian Lissoclinum patella.

Degnan, B. M., Hawkins, C. J., Lavin, M. F., McCaffrey, E. J., Parry, D. L., van den Brenk, A. L. and Watters, D. J. (1989) New cyclic peptides with cytotoxic activity from the ascidian Lissoclinum patella.. Journal of Medicinal Chemistry, 32 6: 1349-1354. doi:10.1021/jm00126a034


Author Degnan, B. M.
Hawkins, C. J.
Lavin, M. F.
McCaffrey, E. J.
Parry, D. L.
van den Brenk, A. L.
Watters, D. J.
Title New cyclic peptides with cytotoxic activity from the ascidian Lissoclinum patella.
Journal name Journal of Medicinal Chemistry   Check publisher's open access policy
ISSN 0022-2623
Publication date 1989-01-01
Year available 1989
Sub-type Article (original research)
DOI 10.1021/jm00126a034
Volume 32
Issue 6
Start page 1349
End page 1354
Total pages 6
Place of publication Easton, Pa.
Publisher American Chemical Society
Language eng
Subject 270200 Genetics
270504 Invertebrate Biology
Abstract The isolation and structures of a new patellamide (patellamide D) and two new lissoclinamides (lissoclinamides 4 and 5) from the aplousobranch ascidian Lissoclinum patella are described. Structures were determined largely by using two-dimensional NMR techniques and mass spectrometry. These peptides and other members of the patellamide and lissoclinamide families that have been reported previously are found withii the obligate algal symbiont of the genus Prochloron. The cytotoxicities of the compounds toward fibroblast and tumor cell lines are reported. One of these comwunds. lissoclinamide 4. is markedlv more toxic than other members of the family. Structureactivity relationships are' discussed.
Keyword peptides
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Degnan Laboratory
School of Biological Sciences Publications
 
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Created: Thu, 06 Dec 2007, 02:51:59 EST by Laura McTaggart