A genomewide survey of developmental genes in Ciona intestinalis: III. Genes for Fox, ETS, nuclear receptors and NF- kB

Yagi, Kasumi, Satou, Yutaka, Mazet, Francoise, Shimeld, Sebastian M., Degnan, Bernard, Rokhsar, Daniel, Levine, Michael, Kohara, Yuji and Satoh, Nori (2003) A genomewide survey of developmental genes in Ciona intestinalis: III. Genes for Fox, ETS, nuclear receptors and NF- kB. Development Genes and Evolution, 213 5-6: 235-244. doi:10.1007/s00427-003-0322-z


Author Yagi, Kasumi
Satou, Yutaka
Mazet, Francoise
Shimeld, Sebastian M.
Degnan, Bernard
Rokhsar, Daniel
Levine, Michael
Kohara, Yuji
Satoh, Nori
Title A genomewide survey of developmental genes in Ciona intestinalis: III. Genes for Fox, ETS, nuclear receptors and NF- kB
Formatted title A genomewide survey of developmental genes in Ciona intestinalis: III. Genes for Fox, ETS, nuclear receptors and NF-KB
Journal name Development Genes and Evolution   Check publisher's open access policy
ISSN 0949-944X
1432-041X
Publication date 2003-06
Sub-type Article (original research)
DOI 10.1007/s00427-003-0322-z
Volume 213
Issue 5-6
Start page 235
End page 244
Total pages 10
Place of publication Heidelberg
Publisher Springer Berlin
Language eng
Subject 270201 Gene Expression
270202 Genome Structure
0604 Genetics
C1
Abstract A survey against the draft genome sequence and the cDNA/EST database of Ciona intestinalis identified a number of genes encoding transcription factors regulating a variety of processes including development. In the present study, we describe almost complete sets of genes for Fox, ETS-domain transcription factors, nuclear receptors, and NFkappaB as well as other factors regulating NFkappaB activity, with their phylogenetic nature. Vertebrate Fox transcription factors are currently delineated into 17 subfamilies: FoxA to FoxQ. The present survey yielded 29 genes of this family in the Ciona genome, 24 of which were Ciona orthologues of known Fox genes. In addition, we found 15 ETS genes, 17 nuclear receptor genes, and several NFkappaB signaling pathway genes in the Ciona genome. The number of Ciona genes in each family is much smaller than that of vertebrates, which represents a simplified feature of the ascidian genome. For example, humans have two NFkappaB genes, three Rel genes, and five NFAT genes, while Ciona has one gene for each family. The Ciona genome also contains smaller numbers of genes for the NFkappaB regulatory system, i.e. after the split of ascidians/vertebrates, vertebrates evolved a more complex NFkappaB system. The present results therefore provide molecular information for the investigation of complex developmental processes, and an insight into chordate evolution.
Keyword Ciona intestinalis
Fox - ETS
Nuclear receptors
NFkappaB
Q-Index Code C1

 
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