The impact of cardiovascular risk factors on the age-related excess risk of coronary heart disease

Jackson, R., Dobson, A., Jamrozik, K. and Asia Pacific Cohort Studies Collaboration (2006) The impact of cardiovascular risk factors on the age-related excess risk of coronary heart disease. International Journal of Epidemiology, 35 4: 1025-1033. doi:10.1093/ije/dyl058

Author Jackson, R.
Dobson, A.
Jamrozik, K.
Asia Pacific Cohort Studies Collaboration
Title The impact of cardiovascular risk factors on the age-related excess risk of coronary heart disease
Journal name International Journal of Epidemiology   Check publisher's open access policy
ISSN 0300-5771
Publication date 2006-08
Sub-type Article (original research)
DOI 10.1093/ije/dyl058
Volume 35
Issue 4
Start page 1025
End page 1033
Total pages 9
Place of publication Oxford, England
Publisher Oxford University Press
Language eng
Subject 1117 Public Health and Health Services
Formatted abstract
Differences in cardiovascular risk factor levels have been suggested to contribute to the age-related excess risk of coronary heart disease (CHD). The aim of this study was to reliably quantify these contributions using a large prospective dataset.


We carried out an individual participant data meta-analysis of 41 cohort studies (n = 582 134) from Asia, and Australia and New Zealand. Cox models were used to estimate hazard ratios for coronary death, comparing individuals aged 55-64, 65-74, and >= 5 yrs with those aged < 55 yrs. Adjustments were made for coronary risk factors to quantify their contributions to the age differential.


During 4.1 million person-years of follow-up, there were 2915 deaths from CHD. The risk of CHD increased substantially with age in all groups, especially in women. Differences in cardiovascular risk factors explained between one-quarter to one-third of the age-related excess of CHD in men and one-half of that in women. Systolic blood pressure was the chief contributor to the excess risk in all groups.


Systolic blood pressure. was the most important modifiable risk factor contributing to the excess CHD risk that occurs with aging in men and women, but in comparison with the effects of age itself, the effects of blood pressure are small.
Keyword Public, Environmental & Occupational Health
Cardiovascular risk factors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 17 Oct 2007, 15:14:22 EST