A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

Stephens, P., Edkins, S., Davies, H., Greenman, C., Cox, C., Hunter, C., Bignell, G., Teague, J., Smith, R., Stevens, C., O'Meara, S., Parker, A., Tarpey, P., Avis, T., Barthorpe, A., Brackenbury, L., Buck, G., Butler, A., Clements, J., Cole, J., Dicks, E., Edwards, K., Forbes, S., Gorton, M., Gray, K., Halliday, K., Harrison, R., Hills, K., Hinton, J., Jones, D., Kosmidou, V., Laman, R., Lugg, R., Menzies, A., Perry, J., Petty, R., Raine, K., Shepherd, R., Small, A., Solomon, H., Stephens, Y., Tofts, C., Varian, J., Webb, A., West, S., Widaa, S., Yates, A., Brasseur, F., Cooper, C.S., Flanagan, A.M., Green, A., Knowles, M., Leung, S.Y., Looijenga, L.H.J., Malkowicz, B., Pierotti, M. A., Teh, B., Yuen, S.T., Nicholson, A.G., Lakhani, S., Easton, D.F., Weber, B.L., Stratton, M.R., Futreal, P.A. and Wooster, R. (2005) A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nature Genetics, 37 6: 590-592. doi:10.1038/ng1571

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Author Stephens, P.
Edkins, S.
Davies, H.
Greenman, C.
Cox, C.
Hunter, C.
Bignell, G.
Teague, J.
Smith, R.
Stevens, C.
O'Meara, S.
Parker, A.
Tarpey, P.
Avis, T.
Barthorpe, A.
Brackenbury, L.
Buck, G.
Butler, A.
Clements, J.
Cole, J.
Dicks, E.
Edwards, K.
Forbes, S.
Gorton, M.
Gray, K.
Halliday, K.
Harrison, R.
Hills, K.
Hinton, J.
Jones, D.
Kosmidou, V.
Laman, R.
Lugg, R.
Menzies, A.
Perry, J.
Petty, R.
Raine, K.
Shepherd, R.
Small, A.
Solomon, H.
Stephens, Y.
Tofts, C.
Varian, J.
Webb, A.
West, S.
Widaa, S.
Yates, A.
Brasseur, F.
Cooper, C.S.
Flanagan, A.M.
Green, A.
Knowles, M.
Leung, S.Y.
Looijenga, L.H.J.
Malkowicz, B.
Pierotti, M. A.
Teh, B.
Yuen, S.T.
Nicholson, A.G.
Lakhani, S.
Easton, D.F.
Weber, B.L.
Stratton, M.R.
Futreal, P.A.
Wooster, R.
Title A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2005-06
Sub-type Article (original research)
DOI 10.1038/ng1571
Volume 37
Issue 6
Start page 590
End page 592
Total pages 3
Place of publication New York, N.Y. U.S.A.
Publisher Nature Publishing Group
Language eng
Subject 1117 Public Health and Health Services
Abstract We examined the coding sequence of 518 protein kinases, similar to 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
Keyword Genetics & Heredity
Saccharomyces-cerevisiae
Genome
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 226 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 233 times in Scopus Article | Citations
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Created: Wed, 17 Oct 2007, 13:38:13 EST