Influence of LRP5 gene polymorphisms on the normal variation of bone mineral density

Koay, MA, Duncan, EL, Ralston, SH, Compston, JE, Cooper, C, Keen, R, Langdahl, BL, MacLelland, A, O'Riordan, J, Pols, HA, Reid, DM, Uitterlinden, AG, Wass, AH and Brown, MA (2004) Influence of LRP5 gene polymorphisms on the normal variation of bone mineral density. Journal of Bone And Mineral Research, 19 10: 1619-1627. doi:10.1359/JBMR.040704


Author Koay, MA
Duncan, EL
Ralston, SH
Compston, JE
Cooper, C
Keen, R
Langdahl, BL
MacLelland, A
O'Riordan, J
Pols, HA
Reid, DM
Uitterlinden, AG
Wass, AH
Brown, MA
Title Influence of LRP5 gene polymorphisms on the normal variation of bone mineral density
Journal name Journal of Bone And Mineral Research   Check publisher's open access policy
ISSN 0884-0431
1523-4681
Publication date 2004-01-01
Year available 2004
Sub-type Article (original research)
DOI 10.1359/JBMR.040704
Volume 19
Issue 10
Start page 1619
End page 1627
Total pages 9
Place of publication Malden, MA United States
Publisher Wiley-Blackwell Publishing, Inc.
Collection year 2005
Language eng
Formatted abstract
Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this study examines the role of the LRP5 gene in determining normal population variation of BMD and describes significant association and suggestive linkage between LRP5 gene polymorphisms and BMD in >900 individuals with a broad range of BMD.
Keyword Endocrinology and Metabolism
Osteoporosis
Single nucleotide polymorphism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Wed, 17 Oct 2007, 22:53:25 EST