Clinical, histopathological and immunological effects of exposure of canine skin to Malassezia pachydermatis

Bond, R, Patterson-Kane, JC and Lloyd, DH (2004) Clinical, histopathological and immunological effects of exposure of canine skin to Malassezia pachydermatis. Medical Mycology, 42 2: 165-175.


Author(s) Bond, R
Patterson-Kane, JC
Lloyd, DH
Title Clinical, histopathological and immunological effects of exposure of canine skin to Malassezia pachydermatis
Journal name Medical Mycology
Publication date 2004
Sub-type Article
Volume number 42
Issue number 2
ISSN 1369-3786
Start page 165
End page 175
Total pages 11
Place of publication Abingdon
Publisher Taylor & Francis Ltd
Abstract The effects of the daily application for 7 days of suspensions of Malassezia pachydermatis to normal canine skin were evaluated in 10 beagle dogs. Four out of six dogs challenged without occlusion developed transient lesions generally characterized clinically by mild erythema with papules and histologically by mild epidermal hyperplasia and a superficial perivascular dermatitis. Saline-treated control sites showed no clinical signs. In four dogs challenged with occlusion, skin lesions occurred at both yeast and saline-treated sites; erythema and papules were more severe at the yeast-treated sites in three dogs. Occlusion induced more persistent lesions, which resolved within 24 days. Population densities of the yeast were highest at day 8 and declined rapidly following cessation of application. Peripheral blood mononuclear cell proliferation indices following M. pachydermatis exposure in vitro and serum concentrations of M. pachydermatis-specific IgG antibodies did not vary significantly during the study. Delayed (24 h) intradermal test reactivity to M. pachydermatis antigens developed in all eight dogs with clinical signs following yeast exposure. This study suggests that the resistance of healthy canine skin to infection by M. pachydermatis is mediated by local delayed hypersensitivity responses and, or innate epidermal immune mechanisms.
Keyword(s) Mycology
Veterinary Sciences
dog
Malassezia pachydermatis
skin
Intradermal Test Reactivity
Pityrosporum-orbiculare
Basset-hounds
Atopic Dogs
Seborrheic-dermatitis
Tinea Versicolor
Healthy Dogs
Infection
Ovale
Populations
 
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