Genetic alterations in pre-invasive lesions

Reis-Filho, Jorge S. and Lakhani, Sunil R. (2003) Genetic alterations in pre-invasive lesions. Breast Cancer Research, 5 6: 313-319. doi:10.1186/bcr650


Author Reis-Filho, Jorge S.
Lakhani, Sunil R.
Title Genetic alterations in pre-invasive lesions
Journal name Breast Cancer Research   Check publisher's open access policy
ISSN 1465-542X
1465-5411
Publication date 2003
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/bcr650
Open Access Status DOI
Volume 5
Issue 6
Start page 313
End page 319
Total pages 7
Place of publication London, UK
Publisher Current Science
Language eng
Abstract The development of modern molecular genetic techniques has allowed breast cancer researchers to clarify the multistep model of breast carcinogenesis. Laser capture microdissection coupled with comparative genomic hybridisation and/or loss-of-heterozygosity methods have confirmed that many pre-invasive lesions of the breast harbour chromosomal abnormalities at loci known to be altered in invasive breast carcinomas. Current data do not provide strong evidence for ductal hyperplasia of usual type as a precursor lesion, although some are monoclonal proliferations; however, atypical hyperplasia and in situ carcinoma appear to be nonobligate precursors. We review current knowledge and the contribution of molecular genetics in the understanding of breast cancer precursors and pre-invasive lesions.
Keyword Oncology
Atypical ductal hyperplasia
Comparative genomic hybridisation
Ductal carcinoma in situ
Lobular carcinoma in situ
Loss of heterozygosity
Carcinoma in-situ
Comparative genomic hybridization
Atypical ductal hyperplasia
E-cadherin
Lobular carcinoma
Microsatellite analysis
Cancer evolution
Chromosome 16q
Allelic loss
Heterozygosity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 17 Oct 2007, 12:21:35 EST