Absorbable deslorelin implants (Ovuplant (R)) prolong postpartum anestrus in early ovulating dairy cows

Padula, A. M., McGowan, M. R. and Macmillan, K. L. (2003) Absorbable deslorelin implants (Ovuplant (R)) prolong postpartum anestrus in early ovulating dairy cows. Theriogenology, 60 7: 1227-1238.


Author Padula, A. M.
McGowan, M. R.
Macmillan, K. L.
Title Absorbable deslorelin implants (Ovuplant (R)) prolong postpartum anestrus in early ovulating dairy cows
Journal name Theriogenology   Check publisher's open access policy
ISSN 0093-691X
Publication date 2003
Sub-type Article (original research)
DOI 10.1016/S0093-691X(03)00143-2
Volume 60
Issue 7
Start page 1227
End page 1238
Total pages 12
Place of publication New York
Publisher Elsevier Science Inc
Language eng
Subject 0707 Veterinary Sciences
0702 Animal Production
Abstract Two experiments were conducted to investigate the use of a bioabsorbable implant of the GnRH agonist deslorelin to temporarily delay the resumption of postpartum ovulatory cycles in Holstein cows. In Experiment 1, recently calved cows were paired and received either a single implant (Ovuplant(R); Peptech Animal Health, Sydney, NSW, Australia) within 48 h of parturition (OVP; n = 17), or remained as untreated controls (CON; n = 17). Blood samples were collected for plasma progesterone assay three times weekly for 6 weeks to profile the pattern of resumption of ovulatory cycles. In Experiment 2, there were 15 CON and 15 OVP cows initially treated as for Experiment 1 as well as 15 OVP + SYNCH cows. Each cow in the CON and OVP + SYNCH groups received a progesterone vaginal insert (CIDR(R); Genetics Australia, Bacchus Marsh, Vic., Australia) for 7 days at 23 days postpartum (23 dpp) to synchronise estrus in cycling animals or to induce an ovulation with estrus in anestrus animals. Blood samples were collected weekly until removal of the CIDR insert, and then twice weekly until 56 dpp to monitor plasma P4 for retrospective determination of ovulation. Milk yield was monitored by twice daily electronic volume measurements and milk composition with once weekly milk composition analysis. In Experiment 1, CON cows began ovulating from 9 dpp; 15 of 17 had ovulated by the end of blood sampling at 42 dpp. None of the OVP cows ovulated until at least 24 dpp, and only 6 of 17 had ovulated by 42 dpp. The average day of first ovulation was extended from 22.4 +/- 2.7 dpp to 39.3 +/- 2.7 dpp (P < 0.05). In Experiment 2, ovulation had occurred in 8 of 15 CON cows at the time of CIDR insertion (23 dpp), 0 of 15 OVP cows and 1 of 15 OVP + SYNCH cows. By 40 dpp (or 10 days following removal of the CIDR insert) every CON cow (15/15) had ovulated, but only 2 of 15 OVP + SYNCH cows and 1 of 15 OVP cows. None of these effects of treatment was associated with any changes in milk yield or composition in either experiment. In conclusion, inserting a bioabsorbable implant of deslorelin within 48 h postpartum extended the interval to first ovulation to at least 24 dpp in 46 of 47 cows. Recovery periods were highly variable. This variability was not reduced by using a form of intravaginal progesterone supplementation that did produce a synchronised estrus with ovulation in anestrus animals that had not been treated with deslorelin. (C) 2003 Elsevier Inc. All rights reserved.
Keyword Reproductive Biology
Veterinary Sciences
dairy cow
GnRH agonist
ovuplant
postpartum
Gnrh Agonist Deslorelin
Cattle
Suppression
Pregnancy
Hormone
Period
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Veterinary Science Publications
 
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