Cognitive control mechanisms revealed by ERP and fMRI: Evidence from repeated task-switching

Swainson, R., Cunnington, R., Jackson, G. M., Rorden, C., Peters, A.M., Morris, P. G. and Jackson, S. R. (2003) Cognitive control mechanisms revealed by ERP and fMRI: Evidence from repeated task-switching. Journal of Cognitive Neuroscience, 15 6: 785-799. doi:10.1162/089892903322370717

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Author Swainson, R.
Cunnington, R.
Jackson, G. M.
Rorden, C.
Peters, A.M.
Morris, P. G.
Jackson, S. R.
Title Cognitive control mechanisms revealed by ERP and fMRI: Evidence from repeated task-switching
Journal name Journal of Cognitive Neuroscience   Check publisher's open access policy
ISSN 0898-929X
Publication date 2003-08-15
Sub-type Article (original research)
DOI 10.1162/089892903322370717
Open Access Status File (Publisher version)
Volume 15
Issue 6
Start page 785
End page 799
Total pages 15
Place of publication Cambridge, MA, United States
Publisher M I T Press
Language eng
Abstract We investigated the extent to which a common neural mechanism is involved in task set-switching and response withholding, factors that are frequently confounded in task-switching and go/no-go paradigms. Subjects' brain activity was measured using event-related electrical potentials (ERPs) and event-related functional MRI (fMRI) neuroimaging in separate studies using the same cognitive paradigm. Subjects made compatible left/right keypress responses to left/right arrow stimuli of 1000 msec duration; they switched every two trials between responding at stimulus onset (GO task-green arrows) and stimulus offset (WAIT task-red arrows). Withholding an immediate response (WAIT vs. GO) elicited an enhancement of the frontal N2 ERP and lateral PFC activation of the right hemisphere, both previously associated with the "no-go" response, but only on switch trials. Task-switching (switch vs. nonswitch) was associated with frontal N2 amplification and right hemisphere ventrolateral PFC activation, but only for the WAIT task. The anterior cingulate cortex (ACC) was the only brain region to be activated for both types of task switch, but this activation was located more rostrally for the WAIT than for the GO switch trials. We conclude that the frontal N2 ERP and lateral PFC activation are not markers for withholding an immediate response or switching tasks per se, hut are associated with switching into a response-suppression mode. Different regions within the ACC may be involved in two processes integral to task-switching: processing response conflict (rostral ACC) and overcoming prior response suppression (caudal ACC).
Keyword Neurosciences
Psychology, Experimental
Event-related Fmri
Inferior Prefrontal Cortex
Anterior Cingulate Cortex
Functional Mri
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 120 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 130 times in Scopus Article | Citations
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Created: Wed, 17 Oct 2007, 12:14:50 EST