Can the stroma provide the clue to the cellular basis for mammographic density?

Warren, R and Lakhani, SR (2003) Can the stroma provide the clue to the cellular basis for mammographic density?. Breast Cancer Research, 5 5: 225-227. doi:10.1186/bcr642


Author Warren, R
Lakhani, SR
Title Can the stroma provide the clue to the cellular basis for mammographic density?
Journal name Breast Cancer Research   Check publisher's open access policy
ISSN 1465-542X
1465-5411
Publication date 2003
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/bcr642
Open Access Status DOI
Volume 5
Issue 5
Start page 225
End page 227
Total pages 3
Place of publication London, United Kingdom
Publisher Biomed Central Ltd
Language eng
Abstract Mammographic density is recognised as a useful phenotypic biomarker of breast cancer risk. Deeper understanding is needed of the cellular basis, but evidence is limited because of difficulty in designing studies to validate hypotheses. The ductal epithelial components do not adequately explain the physical and dynamic features observed. The stroma is thought to interact with ductal structures in cancer initiation. Stromal tissues might account for the mammographic features, and this interplay can be hypothesised to relate risk to density. In a paper in this issue of Breast Cancer Research, Alowami has shown a relationship between density and stromal proteins, which might provide useful insight into mammographic density.
Keyword Oncology
Breast cancer risk
Mammographic density
Stromal proteins
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 17 Oct 2007, 12:13:54 EST