Neuroimmune stress responses: Reciprocal connections between the hypothalamus and the brainstem

Buller, Kathryn M. (2003). Neuroimmune stress responses: Reciprocal connections between the hypothalamus and the brainstem. In: Stress: Proceedings of the 4th World Congress on Stress. 4th World Congress on Stress, Edinburgh, Scotland, (11-17). 12-15 September, 2002. doi:10.1080/1025389031000092313


Author Buller, Kathryn M.
Title of paper Neuroimmune stress responses: Reciprocal connections between the hypothalamus and the brainstem
Conference name 4th World Congress on Stress
Conference location Edinburgh, Scotland
Conference dates 12-15 September, 2002
Proceedings title Stress: Proceedings of the 4th World Congress on Stress   Check publisher's open access policy
Journal name Stress-The International Journal On the Biology of Stress   Check publisher's open access policy
Place of Publication Amsterdam
Publisher Harwood Academic Publishers
Publication Year 2003
Sub-type Fully published paper
DOI 10.1080/1025389031000092313
ISSN 1607-8888
1025-3890
Volume 6
Issue 1
Start page 11
End page 17
Total pages 7
Language eng
Abstract/Summary Hypothalamic nuclei, particularly the paraventricular nuclei (PVN), are important brain sites responsible for eliciting stress responses following a systemic immune challenge. The activation of PVN cells by a systemic immune challenge is critically dependent on the integrity of inputs from brainstem cells situated in the nucleus tractus solitarius (NTS) and ventrolateral medulla (VLM). Interestingly, a descending pathway from the PVN to the brainstem, recruited by systemic immune challenge, might also exist. It is well documented that PVN neurons innervate the NTS and VLM and recent evidence from our laboratory shows that lesions of the PVN reduce brainstem cell responses elicited by a systemic bolus of the proinflammatory cytokine interleukin-1beta (IL-1beta). Although a number of different PVN divisions are candidates for the source of inputs to the brainstem, we have demonstrated that the majority of descending PVN projections recruited by systemic IL-1beta arise from cell bodies localized in the medial and lateral parvocellular PVN. These findings suggest that central nervous system responses to an immune challenge are likely to involve complex reciprocal connections between the PVN and the brainstem, whereby brainstem cell populations could essentially act as integratory sites for descending and ascending immune signals. For instance, these brainstem pathways may have significant implications not only for the regulation of central hypothalamic and extrahypothalamic targets but also the autonomic nervous system.
Subjects 1109 Neurosciences
1116 Medical Physiology
Keyword Behavioral Sciences
Neurosciences
Physiology
HPA axis
interleukin-1 beta
neuroimmune interactions
nucleus tractus solitarius
paraventricular nucleus
ventrolateral medulla
Rostral Ventrolateral Medulla
Corticotropin-releasing-factor
Adrenal Axis Responses
Receptor Messenger-rna
C-fos Protein
Spinal-cord
Paraventricular Nucleus
Rat-brain
Solitary Tract
Interleukin-1 Receptor
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Unknown

 
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Created: Wed, 17 Oct 2007, 12:12:11 EST