Longitudinal investigation of energy expenditure in infants with cystic fibrosis

Davies, P. S. W., Erskine, J. M., Hambidge, K. and Accurso, F. J. (2002) Longitudinal investigation of energy expenditure in infants with cystic fibrosis. European Journal of Clinical Nutrition, 56 10: 940-946. doi:10.1038/sj.ejcn.1601441

Author Davies, P. S. W.
Erskine, J. M.
Hambidge, K.
Accurso, F. J.
Title Longitudinal investigation of energy expenditure in infants with cystic fibrosis
Journal name European Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0954-3007
Publication date 2002-10
Sub-type Article (original research)
DOI 10.1038/sj.ejcn.1601441
Volume 56
Issue 10
Start page 940
End page 946
Total pages 7
Place of publication London
Publisher Nature Publishing Group
Language eng
Subject 11 Medical and Health Sciences
1111 Nutrition and Dietetics
Abstract Objective: To determine when energy expenditure becomes elevated in infants with cystic fibrosis (CF). Design: Longitudinal studies of total energy expenditure (TEE) using doubly labeled water were conducted in infants identified with CF by newborn screening through the first year of life. Setting: Hospital and community based studies in Denver, Colorado, USA and Cambridge, UK. Results: Eight of the 12 infants enrolled had begun enzyme therapy but were clinically asymptomatic. Four of the 12 infants were heterozygous for the delta F508 mutation, however no difference was seen in TEE from the remaining homozygous infants. TEE was compared to control cohorts at 2, 6 and 12 months of age. There was no difference from the control groups in TEE/kg fat free mass (FFM)/day at 2 months. However, by 6 months of age TEE/kg FFM/day in infants with CF exceeded that of age-matched controls by 25% (P < 0.001). This elevation in TEE continued at 12 months of age exceeding that of controls by 30% (P < 0.05). Conclusions: These results indicate that infants with CF have increased energy needs by 6 months of age and that early diagnosis alone does not prevent the development of increased caloric requirements. These findings emphasize the need for close nutritional monitoring to prevent suboptimal growth during infancy in this population. Sponsorship: This research was supported by grant number 5 MO1 RR00069, General Clinical Research Centers Program, National Center for Research Resources, NIH.
Keyword Nutrition & Dietetics
cystic fibrosis
energy expenditure
doubly labeled water
newborn screening
Doubly Labeled Water
Indirect Calorimetry
Preterm Infants
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 17 Oct 2007, 11:36:33 EST