A cardiovascular life history: A life course analysis of the original Framingham Heart Study cohort

Peeters, A., Mamun, A. A., Willekens, F. and Bonneux, L. (2002) A cardiovascular life history: A life course analysis of the original Framingham Heart Study cohort. European Heart Journal, 23 6: 458-466. doi:10.1053/euhj.2001.2838

Author Peeters, A.
Mamun, A. A.
Willekens, F.
Bonneux, L.
Title A cardiovascular life history: A life course analysis of the original Framingham Heart Study cohort
Journal name European Heart Journal   Check publisher's open access policy
ISSN 0195-668X
Publication date 2002-03
Sub-type Article (original research)
DOI 10.1053/euhj.2001.2838
Volume 23
Issue 6
Start page 458
End page 466
Total pages 9
Place of publication London ; New York
Publisher Oxford University Press
Language eng
Subject 1117 Public Health and Health Services
Formatted abstract
Aims. The objective of this paper is to measure the potential burden of cardiovascular disease within the original Framingham Heart Study cohort by transforming its well-described epidemiological measures into time-based health policy measures, such as life years lost to or lived with the disease.
Methods and Results. We constructed multi-state life tables of the Framingham Heart Study cohort to calculate dwelling times with a history of cardiovascular disease. Age-specific probabilities determined transitions from healthy through disease to death. For this synthetic cohort, from age 50 men (women) live on average 26 (32) years, 20 (26) free of cardiovascular disease. Allowing occupancy of more than one disease state. 50-year-old males (females) live 2(.)9 (1(.)2) years with a history of myocardial infarction, 0(.)93 (1(.)2) with a history of stroke, and 0(.)67 (0(.)3) with congestive heart failure. Having ever suffered acute myocardial infarction, stroke or congestive heart failure, life expectancy is reduced by 9 (13), 12 (15) or 16 (16) years, respectively in 60-year-oid men (women).
Conclusions. Transforming occurrence probabilities into time-based health measures, the prevalence of cardiovascular disease is remarkable: from age 50, 20% of remaining life expectancy is lived with the disease. Such measures are integral to appropriate health planning and assessment of the potential population health value of various treatment and prevention strategies.
Keyword Cardiac & Cardiovascular Systems
cardiovascular diseases
Disease Mortality
Smoking Cessation
Framingham Heart Study
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
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Created: Wed, 17 Oct 2007, 10:37:24 EST