Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease

Scott, H. L., Pow, D. V., Tannenberg, A. E. G. and Dodd, P. R. (2002) Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease. Journal of Neuroscience, 22 3: RC206: 1-5.


Author Scott, H. L.
Pow, D. V.
Tannenberg, A. E. G.
Dodd, P. R.
Title Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease
Journal name Journal of Neuroscience   Check publisher's open access policy
Publication date 2002-02
Sub-type Article
Volume number 22
Issue number 3
ISSN 0270-6474
1529-2401
Start page RC206: 1
End page 5
Total pages 5
Place of publication New York
Publisher Society for Neuroscience
Language eng
Subject 110906 Sensory Systems
Abstract Glutamate-mediated toxicity has been implicated in the neurodegeneration observed in Alzheimer's disease. In particular, glutamate transport dysfunction may increase susceptibility to glutamate toxicity, thereby contributing to neuronal cell injury and death. In this study, we examined the cellular localization of the glial glutamate transporter excitatory amino acid transporter 1 (EAAT1) in the cerebral cortex of control, Alzheimer's disease, and non-Alzheimer dementia cases. We found that EAAT1 was strongly expressed in a subset of cortical pyramidal neurons in dementia cases showing Alzheimer-type pathology. In addition, tau (which is a marker of neurofibrillary pathology) colocalized to those same pyramidal cells that expressed EAAT1. These findings suggest that EAAT1 changes are related to tau expression (and hence neurofibrillary tangle formation) in dementia cases showing Alzheimer-type pathology. This study implicates aberrant glutamate transporter expression as a mechanism involved in neurodegeneration in Alzheimer's disease.
Keyword Neurosciences
Alzheimer's disease
glutamate transporter
EAAT1
tau
immunocytochemistry
human cortex
Amyotrophic-lateral-sclerosis
Cerebral-cortex
Protein
Glast
Brain
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Our 1995 paper [42 cites] used classical pharmacological methods; here, we followed up with immunocytochemistry. ‘Hot topic’ in AD.

Document type: Journal Article
Sub-type: Article
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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Created: Wed, 17 Oct 2007, 11:02:44 EST