Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development

Walshe, Jennifer and Mason, Ivor (2003) Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development. Development, 130 18: 4337-4349. doi:10.1242/dev.00660

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Author Walshe, Jennifer
Mason, Ivor
Title Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development
Journal name Development   Check publisher's open access policy
ISSN 0950-1991
Publication date 2003-08
Sub-type Article (original research)
DOI 10.1242/dev.00660
Open Access Status File (Publisher version)
Volume 130
Issue 18
Start page 4337
End page 4349
Total pages 13
Place of publication Cambridge, England
Publisher Company of Biologists
Language eng
Subject 1199 Other Medical and Health Sciences
Abstract Complex spatiotemporal expression patterns of fgf3 and fgf8 within the developing zebrafish forebrain suggest their involvement in its regionalisation and early development. These factors have unique and combinatorial roles during development of more posterior brain regions, and here we report similar findings for the developing forebrain. We show that Fgf8 and Fgf3 regulate different aspects of telencephalic development, and that Fgf3 alone is required for the expression of several telencephalic markers. Within the diencephalon, Fgf3 and Fgf8 act synergistically to pattern the ventral thalamus, and are implicated in the regulation of optic stalk formation, whereas loss of Fgf3 alone results in defects in ZLI development. Forebrain commissure formation was abnormal in the absence of either Fgf3 or Fgf8; however, most severe defects were observed in the absence of both. Defects were observed in patterning of both the midline territory, within which the commissures normally form, and neuronal populations, whose axons comprise the commissures. Analysis of embryos treated with an FGFR inhibitor suggests that continuous FGF signalling is required from gastrulation stages for normal forebrain patterning, and identifies additional requirements for FGFR activity.
Keyword Commissure
Diencephalon
FGF
Forebrain
Telencephalon
Thalamus
Zebrafish
Zona limitans intrathalamica
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
UQ Centre for Clinical Research Publications
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 90 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 94 times in Scopus Article | Citations
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Created: Mon, 06 Feb 2006, 23:00:30 EST