Phosphoinositides as key regulators of synaptic function

Osborne, Shona L., Meunier, Frédéric A. and Schiavo, Giampietro (2001) Phosphoinositides as key regulators of synaptic function. Neuron, 32 1: 9-12. doi:10.1016/S0896-6273(01)00455-X


Author Osborne, Shona L.
Meunier, Frédéric A.
Schiavo, Giampietro
Title Phosphoinositides as key regulators of synaptic function
Journal name Neuron   Check publisher's open access policy
ISSN 0896-6273
Publication date 2001
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0896-6273(01)00455-X
Volume 32
Issue 1
Start page 9
End page 12
Total pages 4
Place of publication Cambridge
Publisher Cell Press
Language eng
Subject 06 Biological Sciences
Abstract Phosphoinositides have recently emerged as key regulators of a variety of synaptic processes, including neurosecretory vesicle targeting, exo-endocytosis, and ion channel modulation. These pleiotropic activities derive from their ability to serve either as membrane targeting sites for cytosolic factors, as allosteric ligands, or as nucleation points for coat proteins and cytoskeletal elements. This versatility depends upon the existence of highly diversified enzymatic machinery for their synthesis and degradation, which governs, both temporally and spatially, their appearance in the microenvironment of the synapse.
Keyword Neurosciences
Actin Cytoskeleton
Endocytosis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
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Created: Wed, 17 Oct 2007, 11:00:32 EST