CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation

Jones, C., Nonni, A. V., Fulford, L., Merrett, S., Chaggar, R., Eusebi, V. and Lakhani, S. R. (2001) CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation. British Journal of Cancer, 85 3: 422-427. doi:10.1054/bjoc.2001.1869


Author Jones, C.
Nonni, A. V.
Fulford, L.
Merrett, S.
Chaggar, R.
Eusebi, V.
Lakhani, S. R.
Title CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
1532-1827
Publication date 2001-07
Sub-type Article (original research)
DOI 10.1054/bjoc.2001.1869
Open Access Status DOI
Volume 85
Issue 3
Start page 422
End page 427
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract 2-18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14 expression were further characterized by immunohistochemistry for myoepithelial cell phenotype and analysed by comparative genomic hybridization. The 7 cases of ductal carcinoma-NST exhibiting a basal cell phenotype were all grade III tumours and showed a molecular cytogenetic profile similar to more conventional myoepithelial cell carcinomas. Therefore it appears that grade Ill invasive ductal carcinomas contain a subset of tumours with specific morphological and cytogenetic characteristics, and probably prognosis for the patient. (C) 2001 Cancer Research Campaign.
Keyword Oncology
CGH
Myoepithelial
Ductal carcinoma
Breast
Keratin 14
Basal cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Oct 2007, 10:37:41 EST