Coupling hydrophilic amine-containing molecules to the backbone of poly(ε-caprolactone)

Prime, Emma L., Cooper-White, Justin J. and Qiao, Greg G. (2006) Coupling hydrophilic amine-containing molecules to the backbone of poly(ε-caprolactone). Australian Journal of Chemistry, 59 8: 534-538. doi:10.1071/CH06144


Author Prime, Emma L.
Cooper-White, Justin J.
Qiao, Greg G.
Title Coupling hydrophilic amine-containing molecules to the backbone of poly(ε-caprolactone)
Journal name Australian Journal of Chemistry   Check publisher's open access policy
ISSN 0004-9425
1445-0038
Publication date 2006-09
Sub-type Article (original research)
DOI 10.1071/CH06144
Volume 59
Issue 8
Start page 534
End page 538
Total pages 5
Place of publication Collingwood, VIC, Australia
Publisher C S I R O Publishing
Language eng
Abstract A poly(ε-caprolactone) (PCL) based biodegradable polymer containing robust, amine-reactive side chains has been successfully synthesized. The specific reactivity of the side chains allows for the coupling of unmodified amine-containing molecules such as poly(L-lysine) (PLL) to PCL to occur in the presence of other unprotected functional groups. The reactivity of this polymer has been demonstrated through successful coupling of both benzylamine (a model compound) and PLL. This novel amine-reactive polymer could have numerous applications in biomedical fields such as tissue engineering and drug delivery.
Keyword Chemistry, Multidisciplinary
Ring-opening Polymerization
Aliphatic Polyesters
Biodegradable Polymers
Click Chemistry
Copolymerization
Ligands
Peptide
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes This paper was taken from a presentation by Emma Prime that won the 2006 Treloar Prize for the best oral presentation at the 28th Australian Polymer Symposium.

 
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Created: Wed, 19 Sep 2007, 17:52:24 EST