Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner

Avadhanula, Vasanthi, Rodriguez, Carina A., DeVincenzo, John P., Wang, Yan, Webby, Richard J., Ulett, Glen C. and Adderson, Elisabeth E. (2006) Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner. Journal of Virology, 80 4: 1629-1636. doi:10.1128/JVI.80.4.1629-1636.2006

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Author Avadhanula, Vasanthi
Rodriguez, Carina A.
DeVincenzo, John P.
Wang, Yan
Webby, Richard J.
Ulett, Glen C.
Adderson, Elisabeth E.
Title Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 2006-02-01
Year available 2006
Sub-type Article (original research)
DOI 10.1128/JVI.80.4.1629-1636.2006
Open Access Status File (Publisher version)
Volume 80
Issue 4
Start page 1629
End page 1636
Total pages 8
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Secondary bacterial infections often complicate respiratory viral infections, but the mechanisms whereby viruses predispose to bacterial disease are not completely understood. We determined the effects of infection with respiratory syncytial virus (RSV), human parainfluenza virus 3 (HPIV-3), and influenza virus on the abilities of nontypeable Haemophilus influenzae and Streptococcus pneumoniae to adhere to respiratory epithelial cells and how these viruses alter the expression of known receptors for these bacteria. All viruses enhanced bacterial adhesion to primary and immortalized cell lines. RSV and HPIV-3 infection increased the expression of several known receptors for pathogenic bacteria by primary bronchial epithelial cells and A549 cells but not by primary small airway epithelial cells. Influenza virus infection did not alter receptor expression. Paramyxoviruses augmented bacterial adherence to primary bronchial epithelial cells and immortalized cell lines by up-regulating eukaryotic cell receptors for these pathogens, whereas this mechanism was less significant in primary small airway epithelial cells and in influenza virus infections. Respiratory viruses promote bacterial adhesion to respiratory epithelial cells, a process that may increase bacterial colonization and contribute to disease. These studies highlight the distinct responses of different cell types to viral infection and the need to consider this variation when interpreting studies of the interactions between respiratory cells and viral pathogens.
Keyword Virology
Nontypable Haemophilus-influenzae
Obstructive Pulmonary-disease
Platelet-activating-factor
Syncytial-virus
Streptococcus-pneumoniae
Lethal Synergism
Tract Infections
Factor Receptor
Expression
Children
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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Created: Thu, 20 Sep 2007, 04:46:04 EST