A methodology for quality control in cell nucleus segmentation

Bamford, Pascal and Lovell, Brian C. (1999). A methodology for quality control in cell nucleus segmentation. In: , Proceedings of the Digital Image Computing: Techniques & Applications. Digital Image Computing: Techniques and Applications, Perth, Australia, (21-25). 7th - 8th December, 1999.

 
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Author(s) Bamford, Pascal
Lovell, Brian C.
Title of paper A methodology for quality control in cell nucleus segmentation
Conference name Digital Image Computing: Techniques and Applications
Conference location Perth, Australia
Conference dates 7th - 8th December, 1999
Proceedings title Proceedings of the Digital Image Computing: Techniques & Applications
Place published Perth
Publisher Australian Pattern Recognition Society
Publication date 1999
Volume number 1
ISBN 1863428380
Start page 21
End page 25
Total pages 5
Language eng
Abstract/Summary In order to achieve the very high accuracy rates required in unsupervised automated biomedical applications, it is often necessary to complement a successful segmentation algorithm with a robust error checking stage. The better the segmentation strategy, the less severe the error checking decisions need to be and the fewer correct segmentations that are discarded. These issues are dealt with in this paper in order to achieve 100% accuracy on a data set of 19946 cell nucleus images using an established segmentation scheme with a success rate of 99.47%. The method is based upon measuring changes in the final segmentation contour as the one parameter that governs its behaviour is varied. 1. Introduction remove potential artefacts based on shape and appearance that was capable of detecting some of the incorrectly segmented nuclei [9]. Nordin describes an algorithm that is able to report a failure at various levels of segmentation, as well as a separate artefact rejection stage [11]. McKenna used a neural network to preselect potential nuclei in scenes for subsequent segmentation. It was pointed out that a post-processing stage would also be necessary to filter out 'erroneously detected objects'[10]. A common trait in these techniques is the use of a separate process to view the output of the segmentation and to use shape and appearance measurements to classify the results as 'pass' (looks like a cell) or 'fail' (doesn't look like a cell). We have proposed a segmentation scheme that not only employs an algorithm with much better performance than previously reported [3], but also enables a confidence measure in the resulting segmentation to be given.
Subjects 280000 Information, Computing and Communication Sciences
E1
780108 Behavioural and cognitive sciences
280208 Computer Vision
Keyword(s) iris-research
segmentation algorithm
cell nucleus images
 
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