The transcriptional landscape of the mammalian genome

The FANTOM Consortium, Gough, J., Frith, M. C., Ravasi, T., Wells, C., Forrest, A. R. R., Davis, M. J., Aturaliya, R. N., Bailey, T. L., Crowe, M. L., Faulkner, G., Pang, K. C., Teasdale, R. D., Grimmond, S. M., Mattick, J. S., Hume, D. A. and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Core Team) (2005) The transcriptional landscape of the mammalian genome. Science, 309 5740: 1559-1563. doi:10.1126/science.1112014


Author The FANTOM Consortium
Gough, J.
Frith, M. C.
Ravasi, T.
Wells, C.
Forrest, A. R. R.
Davis, M. J.
Aturaliya, R. N.
Bailey, T. L.
Crowe, M. L.
Faulkner, G.
Pang, K. C.
Teasdale, R. D.
Grimmond, S. M.
Mattick, J. S.
Hume, D. A.
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Core Team)
Title The transcriptional landscape of the mammalian genome
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
1095-9203
Publication date 2005-09-02
Sub-type Article (original research)
DOI 10.1126/science.1112014
Volume 309
Issue 5740
Start page 1559
End page 1563
Total pages 5
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Collection year 2005
Language eng
Subject 230203 Statistical Theory
270202 Genome Structure
360100 Political Science
CX
06 Biological Sciences
060102 Bioinformatics
060407 Genome Structure and Regulation
060114 Systems Biology
Abstract This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
Keyword Multidisciplinary Sciences
Gene-expression
Mouse
Identification
Human-chromosome-21
Annotation
Sequences
Arrays
Rnas
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Wed, 19 Sep 2007, 18:50:50 EST