Acute effects of parainfluenza virus on epithelial electrolyte transport

Kunzelmann, Karl, Konig, Jens, Sun, Jane, Markovich, D., King, Nicholas J., Karupiah, Guna, Young, John A. and Cook, David I. (2004) Acute effects of parainfluenza virus on epithelial electrolyte transport. Journal of Biological Chemistry, 279 47: 48760-48766. doi:10.1074/jbc.M409747200

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Author Kunzelmann, Karl
Konig, Jens
Sun, Jane
Markovich, D.
King, Nicholas J.
Karupiah, Guna
Young, John A.
Cook, David I.
Title Acute effects of parainfluenza virus on epithelial electrolyte transport
Journal name Journal of Biological Chemistry   Check publisher's open access policy
ISSN 0021-9258
Publication date 2004-11-19
Sub-type Article (original research)
DOI 10.1074/jbc.M409747200
Open Access Status File (Publisher version)
Volume 279
Issue 47
Start page 48760
End page 48766
Total pages 7
Place of publication Bethesda, MD
Publisher Amer Soc Biochemistry Molecular Biology Inc
Language eng
Subject 06 Biological Sciences
Abstract Parainfluenza viruses are important causes of respiratory disease in both children and adults. In particular, they are the major cause of the serious childhood illness croup (laryngotracheobronchitis). The infections produced by parainfluenza viruses are associated with the accumulation of ions and fluid in the respiratory tract. It is not known, however, whether this accumulation is because of a direct effect of the viruses on ion and fluid transport by the respiratory epithelium. Here we show that a model parainfluenza virus (the Sendai virus), in concentrations observed during respiratory infections, activates Cl- secretion and inhibits Na+ absorption across the tracheal epithelium. It does so by binding to a neuraminidase-insensitive glycolipid, possibly asialo-GM1, triggering the release of ATP, which then acts in an autocrine fashion on apical P2Y receptors to produce the observed changes in ion transport. These findings indicate that fluid accumulation in the respiratory tract associated with parainfluenza virus infection is attributable, at least in part, to direct effects of the virus on ion transport by the respiratory epithelium.
Keyword Biochemistry & Molecular Biology
Sensitive Na+ Absorption
Cystic-fibrosis Airways
Collecting Duct Cells
Tracheal Epithelium
Extracellular Nucleotides
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 31 times in Scopus Article | Citations
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Created: Wed, 19 Sep 2007, 18:49:45 EST