Interparticle van der Waals force in powder flowability and compactibility

Li, Qin, Rudolph, Victor, Weigl, Bernhard and Earl, Alan (2004) Interparticle van der Waals force in powder flowability and compactibility. International Journal of Pharmaceutics, 280 1-2: 77-93. doi:10.1016/j.ijpharm.2004.05.001

Author Li, Qin
Rudolph, Victor
Weigl, Bernhard
Earl, Alan
Title Interparticle van der Waals force in powder flowability and compactibility
Journal name International Journal of Pharmaceutics   Check publisher's open access policy
ISSN 0378-5173
Publication date 2004
Sub-type Article (original research)
DOI 10.1016/j.ijpharm.2004.05.001
Volume 280
Issue 1-2
Start page 77
End page 93
Total pages 17
Place of publication Amsterdam
Publisher Elsevier Science Bv
Language eng
Subject 290699 Chemical Engineering not elsewhere classified
Abstract Particle flowability and compactibility are the two critical process parameters tested when a pharmaceutical material is formulated for a tabletting process. These behavioral descriptions are strongly affected by geometrical, physical, chemical and mechanical particle properties, as well as operational conditions. The property influences are broadly known in a qualitative sense, but have largely escaped fundamental quantitative description. Various measurement methods have been separately developed for each of these properties which provide comparative indices to assist in process and formulation design. This paper seeks to establish the connections between interparticle van der Waals force and both flowability and compactibility, and therefore also the inter-relations between the two apparently distinct properties. Paracetamol and the excipients often associated with it for tabletting are used as test materials to provide an initial validation of the theoretical development. These powders are well-characterized and known to be particularly difficult with respect to flowability and compactibility. (C) 2004 Elsevier B.V. All rights reserved.
Keyword Pharmacology & Pharmacy
interparticle adhesion force
van der Waals force
Hausner ratio
tablet strength
Nanoscale Rough Surfaces
Sintered-like Crystals
Direct Compression
Pure Paracetamol
Tablet Bond
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemical Engineering Publications
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Created: Wed, 19 Sep 2007, 18:04:08 EST