Evolution and comparative genomics of odorant-and pheromone-associated genes in rodents

Emes, Richard D., Beatson, Scott A., Ponting, Chris P. and Goodstadt, Leo (2004) Evolution and comparative genomics of odorant-and pheromone-associated genes in rodents. Genome Research, 14 4: 591-602. doi:10.1101/gr.1940604

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Author Emes, Richard D.
Beatson, Scott A.
Ponting, Chris P.
Goodstadt, Leo
Title Evolution and comparative genomics of odorant-and pheromone-associated genes in rodents
Journal name Genome Research   Check publisher's open access policy
ISSN 1088-9051
Publication date 2004-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1101/gr.1940604
Open Access Status File (Publisher version)
Volume 14
Issue 4
Start page 591
End page 602
Total pages 12
Place of publication Cold Spring Harbor, NY, United States
Publisher Cold Spring Harbor Lab Press
Language eng
Abstract Chemical cues influence a range of behavioral responses in rodents. The involvement of protein odorants and odorant receptors in mediating reproductive behavior, foraging, and predator avoidance suggests that their genes may have been subject to adaptive evolution. We have estimated the consequences of selection on rodent pheromones, their receptors, and olfactory receptors. These families were chosen on the basis of multiple gene duplications since the common ancestor of rat and mouse. For each family, codons were identified that are likely to have been subject to adaptive evolution. The majority of such sites are Situated on the solvent-accessible surfaces of Putative pheromones and the lumenal portions of their likely receptors. We predict that these contribute to physicochemical and functional diversity within pheromone-receptor interaction sites.
Keyword Biochemistry & Molecular Biology
Biotechnology & Applied Microbiology
Genetics & Heredity
Protein-coupled Receptors
Codon-substitution Models
Major Urinary Proteins
Amino-acid Sites
Metabotropic Glutamate-receptor
X-ray Crystallography
Olfactory Receptor
Positive Selection
Molecular Adaptation
Vomeronasal Receptor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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Created: Wed, 19 Sep 2007, 19:04:43 EST